机构：[1]Institute of Biomedical Engineering, West China Medical Center of Sichuan University, Chengdu 610041, China[2]Sichuan cancer hospital & research institute, Chengdu 610041, China四川省肿瘤医院
In the present study, we have demonstrated that alginate and collagen sponge can act as scaffolds in order to support 3-dimensional structure for the differentiated bone marrow derived mesenchymal stem cells (BMSCs) during chondrogenesis in vitro and in vivo. The chondrogenic induced BMSCs were well distributed and differentiation in scaffolds system before implantation, then they produced sufficient ECM in the implants to form chondroid aggregates in vivo. In our opinion, well-differentiated BMSCs is a crucial feature of cartilage repair and only can be achieved in scaffold matrix. Furthermore, when dealing with cartilage defects, alginate seem to be superior to collagen sponge, and the combinational strategy of pre-induced BMSCs combined with alginate 3D-culture might be useful in improving conventional autologous cells transplantation or free-cells scaffolds.
基金：
National Natural Science Foundation of China.National Natural Science Foundation of China [10802054, 30700149]
语种：
外文
被引次数：
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第一作者：
第一作者机构：[1]Institute of Biomedical Engineering, West China Medical Center of Sichuan University, Chengdu 610041, China
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推荐引用方式(GB/T 7714)：
Wu Jiang,Wang Guang-hui,Zhang Hong,et al.Chondrogenic Ability of Bone Marrow Mesenchymal Stem Cells in Alginate And Collagen Sponge[J].ADVANCED MATERIALS AND COMPUTER SCIENCE, PTS 1-3.2011,474-476:1935-+.doi:10.4028/www.scientific.net/KEM.474-476.1935.
APA：
Wu, Jiang,Wang, Guang-hui,Zhang, Hong,Wu, Yu-ping,Lv, Yang-cheng...&Zhu, Jiang.(2011).Chondrogenic Ability of Bone Marrow Mesenchymal Stem Cells in Alginate And Collagen Sponge.ADVANCED MATERIALS AND COMPUTER SCIENCE, PTS 1-3,474-476,
MLA：
Wu, Jiang,et al."Chondrogenic Ability of Bone Marrow Mesenchymal Stem Cells in Alginate And Collagen Sponge".ADVANCED MATERIALS AND COMPUTER SCIENCE, PTS 1-3 474-476.(2011):1935-+
