机构：[1]Department of Orthopaedics, Orthopaedics Institute, Subei People’s Hospital of Jiangsu Province, Yangzhou, Jiangsu, China[2]Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, WV, USA[3]Department of Orthopaedics, Chengdu Military General Hospital, Chengdu, Sichuan, China[4]Exercise Physiology, West Virginia University, Morgantown, WV, USA[5]Mary Babb Randolph Cancer Center, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV, USA
Growing evidence indicates that infrapatellar fat pad (IPFP)-derived stem cells (IPFSCs) exert robust proliferation capacities and multilineage differentiation potentials. However, few papers summarize the advantages that the IPFP and IPFSCs have in regenerative medicine. In this review we delineate the development and anatomy of the IPFP by comparing it with an adjacent fibrous tissue, synovium, and a more frequently harvested fat depot, subcutaneous adipose tissue. Furthermore, we explore the similarities and differences of stem cells from these three tissues in terms of IPFSCs, synovium-derived stem cells and subcutaneous adipose tissue-derived stem cells in proliferation capacity and tri-lineage differentiation potentials, including chondrogenesis, osteogenesis and adipogenesis. Finally, we highlight the advantages of IPFSCs in regenerative medicine, such as the abundant accessibility and the ability to resist inflammation and senescence, two hurdles for cell-based tissue regeneration. Considering the comparative advantages of IPFSCs, the IPFP can serve as an excellent stem cell source for regenerative medicine, particularly for cartilage regeneration.
基金：
Musculoskeletal Transplant Foundation the
National Institutes of Health (1R03AR062763-01A1 and
1R01AR067747-01A1 to M.P.) and a Study Abroad
Scholarship from Jiangsu Province and Jiangsu Province
Youth Medical Talents (QNRC2016344) to Y.S.
第一作者机构：[1]Department of Orthopaedics, Orthopaedics Institute, Subei People’s Hospital of Jiangsu Province, Yangzhou, Jiangsu, China[2]Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, WV, USA
通讯作者：
通讯机构：[2]Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, WV, USA[4]Exercise Physiology, West Virginia University, Morgantown, WV, USA[5]Mary Babb Randolph Cancer Center, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV, USA[*1]Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, PO Box 9196, One Medical Center Drive, Morgantown, WV 26506-9196, USA
推荐引用方式(GB/T 7714)：
Sun Yu,Chen Song,Pei Ming.Comparative advantages of infrapatellar fat pad: an emerging stem cell source for regenerative medicine.[J].Rheumatology (Oxford, England).2018,57(12):2072-2086.doi:10.1093/rheumatology/kex487.
APA：
Sun Yu,Chen Song&Pei Ming.(2018).Comparative advantages of infrapatellar fat pad: an emerging stem cell source for regenerative medicine..Rheumatology (Oxford, England),57,(12)
MLA：
Sun Yu,et al."Comparative advantages of infrapatellar fat pad: an emerging stem cell source for regenerative medicine.".Rheumatology (Oxford, England) 57..12(2018):2072-2086
医学