机构：[1]School of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China,[2]College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China,[3]School of Pharmacy, Chongqing Medical University, Chongqing 400042, China,[4]Sichuan Tumor Hospital, Chengdu 610041, China,四川省肿瘤医院[5]West China School of Pharmacy, Sichuan University, Chengdu 610041, China
This study developed a carrier for anticancer drug, cisplatin. Cisplatin-loaded niosomes (CP-NMs) were prepared under optimized conditions with Span 40 and cholesterol as the excipients, and then lyophilized and characterized. Their anticancer efficacy was tested in rabbits bearing VX2 sarcoma. The obtained spherical-looking vesicles showed a diameter of 7.73 +/- 1.49 mu m with a zeta-potential of 0 mV. The entrapment efficiency was 76.93 +/- 2.67%, and drug loading 2.96 +/- 0.10%. In vitro release tests gave a t(50%) of 8.36 h. The rabbits locally injected with the CP-NMs gave significantly superior results of inhibition of tumour growth, much lower mortality and improved results of body weight change and inhibition of tumour metastasis to inguinal lymph nodes and liver compared to those treated in the same way with the drug solution. The inspiring anticancer results indicated that the CP-NMs might be developed as an effective anticancer preparation with low toxicity.
基金：
This study was financially supported by the
National Science Foundation of China (no. 35072262),
and the project was also funded by the Priority Academic Program Development of Jiangsu Higher Education
Institution.
第一作者机构：[1]School of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China,[*1]School of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China.
通讯作者：
通讯机构：[1]School of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China,[*1]School of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China.
推荐引用方式(GB/T 7714)：
Hong Yang,Anping Deng,Jingqing Zhang,et al.Preparation, characterization and anticancer therapeutic efficacy of cisplatin-loaded niosomes[J].JOURNAL OF MICROENCAPSULATION.2013,30(3):237-244.doi:10.3109/02652048.2012.717116.
APA：
Hong Yang,Anping Deng,Jingqing Zhang,Jian Wang&Bin Lu.(2013).Preparation, characterization and anticancer therapeutic efficacy of cisplatin-loaded niosomes.JOURNAL OF MICROENCAPSULATION,30,(3)
MLA：
Hong Yang,et al."Preparation, characterization and anticancer therapeutic efficacy of cisplatin-loaded niosomes".JOURNAL OF MICROENCAPSULATION 30..3(2013):237-244
