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Role of body mass index and weight change in the risk of cancer: A systematic review and meta-analysis of 66 cohort studies

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机构： [1]Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China. [2]The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China. [3]The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China. [4]Thoracic Surgery Branch, Centre for Cancer Research, National Institutes of Health, Bethesda, Maryland, USA. [5]Department of Aetiology and Carcinogenesis, National Cancer Centre, National Clinical Research Centre for Cancer, Cancer Hospital, Changping Laboratory, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. [6]Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. [7]Key Laboratory of Proteomics, Beijing Proteome Research Centre, National Centre for Protein Sciences, Beijing Institute of Lifeomics, Beijing, China. [8]Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Pathophysiology, Peking Union Medical College, Beijing, China. [9]Department of Respiratory and Critical Care Medicine, Sixth People's Hospital of Chengdu, Chengdu, Sichuan, China. [10]Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China. [11]National Clinical Research Centre for Geriatric Disorders, Xiangya Hospital, Central South University, Hunan, China.

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This study was designed to evaluate the effects of body mass index (BMI) and weight change on the risk of developing cancer overall and cancer at different sites.We searched PubMed and other databases up to July 2023 using the keywords related to 'risk', 'cancer', 'weight', 'overweight', and 'obesity'. We identified eligible studies, and the inclusion criteria encompassed cohort studies in English that focused on cancer diagnosis and included BMI or weight change as an exposure factor. Multiple authors performed data extraction and quality assessment, and statistical analyses were carried out using RevMan and R software. We used random- or fixed-effects models to calculate the pooled relative risk (RR) or hazard ratio along with 95% confidence intervals (CIs). We used the Newcastle-Ottawa Scale to assess study quality.Analysis included 66 cohort studies. Compared to underweight or normal weight, overweight or obesity was associated with an increased risk of endometrial cancer, kidney cancer, and liver cancer but a decreased risk of prostate cancer and lung cancer. Being underweight was associated with an increased risk of gastric cancer and lung cancer but not that of postmenopausal breast cancer or female reproductive cancer. In addition, weight loss of more than five kg was protective against overall cancer risk.Overweight and obesity increase the risk of most cancers, and weight loss of >5 kg reduces overall cancer risk. These findings provide insights for cancer prevention and help to elucidate the mechanisms underlying cancer development.Reviewregistry1786.Copyright © 2024 by the Journal of Global Health. All rights reserved.

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大类 | 3 区医学

小类 | 3 区公共卫生、环境卫生与职业卫生

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无

最新[2023]版：

Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

影响因子： 4.5 最新[2023版] 5.3 最新五年平均 4.5 出版当年[2023版] 0 出版当年五年平均 4.5 出版前一年[2023版]

第一作者：

第一作者机构： [1]Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China. [2]The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China.

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通讯作者：

通讯机构： [1]Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China. [10]Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China. [11]National Clinical Research Centre for Geriatric Disorders, Xiangya Hospital, Central South University, Hunan, China. [*1]Xiangya Hospital, Central South University No.87 Xiangya Road, Changsha, Hunan China [*2]Zhujiang Hospital, Southern Medical University 253 Industrial Avenue, Guangzhou, Guangdong China

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Role of body mass index and weight change in the risk of cancer: A systematic review and meta-analysis of 66 cohort studies $(function () { $("[data-toggle='tooltip']").tooltip(); });

文献详情

Role of body mass index and weight change in the risk of cancer: A systematic review and meta-analysis of 66 cohort studies