机构：[1]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, PR China四川大学华西医院[2]Department of Radiation Oncology, Sichuan Cancer Hospital, Chengdu, Sichuan, PR China四川省肿瘤医院[3]Graduate School, Guangxi Medical University, Nanning, Guangxi, PR China
Here, we investigated the molecular mechanism underlying the changes in the distribution of nucleolin. Our study identified PI3K/Akt signaling as an essential pathway regulating the distribution of nucleolin. Furthermore, nucleolin can interact with phospho-PI3K-p55, and changes in the distribution of nucleolin were related to its phosphorylation. Subsequently, we analyzed the correlation of VEGF and nucleolin, and found that distribution of nucleolin related to metastatic potential. Finally, blocking cell surface nucleolin influences the process of epithelial-mesenchymal transitions. This indicates that nucleolin may be a novel cancer therapy target and a predictive marker for tumor migration in colorectal carcinoma. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
基金：
National Key Basic Research Program of ChinaNational Basic Research Program of China [2010 CB 529900]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81102062, 81071818]
第一作者机构：[1]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, PR China
共同第一作者：
通讯作者：
通讯机构：[1]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, PR China[*1]State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Gaopeng Street, Keyuan Road 4, Chengdu 610041, PR China
推荐引用方式(GB/T 7714)：
Wu Dong-ming,Zhang Peng,Liu Ru-yan,et al.Phosphorylation and changes in the distribution of nucleolin promote tumor metastasis via the PI3K/Akt pathway in colorectal carcinoma[J].FEBS LETTERS.2014,588(10):1921-1929.doi:10.1016/j.febslet.2014.03.047.
APA：
Wu, Dong-ming,Zhang, Peng,Liu, Ru-yan,Sang, Ya-xiong,Zhou, Cong...&Wang, Chun-ting.(2014).Phosphorylation and changes in the distribution of nucleolin promote tumor metastasis via the PI3K/Akt pathway in colorectal carcinoma.FEBS LETTERS,588,(10)
MLA：
Wu, Dong-ming,et al."Phosphorylation and changes in the distribution of nucleolin promote tumor metastasis via the PI3K/Akt pathway in colorectal carcinoma".FEBS LETTERS 588..10(2014):1921-1929
