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Tumor-associated macrophages promote bladder tumor growth through PI3K/AKT signal induced by collagen.

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机构： [1]Department of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, China [2]Center of Biomedical Big Data, West China Hospital, Sichuan University, Chengdu, China [3]National Clinical Research Center of Geriatrics, The Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, China [4]Department of Pathology, West China Hospital, Sichuan University, Chengdu, China [5]Health Ministry Key Laboratory of Chronobiology, College of Basic Medicine and Forensic Medicine, Sichuan University, Chengdu, China

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关键词： bladder cancer collagen integrin α2β1 PI3K/AKT tumor‐associated macrophages

摘要：

The tumor microenvironment is associated with various tumor progressions, including cancer metastasis, immunosuppression, and tumor sustained growth. Tumor-associated macrophages (TAMs) are considered an indispensable component of the tumor microenvironment, participating in the progression of tumor microenvironment remodeling and creating various compounds to regulate tumor activities. This study aims to observe enriched TAMs in tumor tissues during bladder cancer development, which markedly facilitated the proliferation of bladder cancer cells and promoted tumor growth in vivo. We determined that TAMs regulate tumor sustained growth by secreting type I collagen, which can activate the prosurvival integrin α2β1/PI3K/AKT signaling pathway. Furthermore, traditional chemotherapeutic drugs combined with integrin α2β1 inhibitor showed intensive anticancer effects, revealing an innovative approach in clinical bladder cancer treatment. © 2019 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

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出版当年[2019]版：

大类 | 2 区医学

小类 | 2 区肿瘤学

最新[2023]版：

大类 | 2 区

医学

小类 | 2 区肿瘤学

第一作者：

第一作者机构： [1]Department of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, China [2]Center of Biomedical Big Data, West China Hospital, Sichuan University, Chengdu, China

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通讯作者：

通讯机构： [1]Department of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, China [*1]Department of Urology, Institute of Urology, West China Hospital of Sichuan University, Chengdu, China.

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Tumor-associated macrophages promote bladder tumor growth through PI3K/AKT signal induced by collagen.

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