机构：[1]Sichuan Provincial Key Laboratory for Human Disease Gene Studyand Institute of Laboratory Medicine, Hospital of University of ElectronicScience and Technology of China and Sichuan Provincial People’s Hospital,Chengdu 610072, Sichuan, People’s Republic of China四川省人民医院[2]Organ TransplantCentre, Hospital of University of Electronic Science and Technology of Chinaand Sichuan Provincial People’s Hospital, Chengdu 610072, Sichuan, People’sRepublic of China四川省人民医院[3]Health Management Center, Hospital of Universityof Electronic Science and Technology of China and Sichuan Provincial People’sHospital, Chengdu 610072, Sichuan, People’s Republic of China四川省人民医院[4]Schoolof Medicine, University of Electronic Science and Technology of China,Chengdu 610072, Sichuan, People’s Republic of China
Background: Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a newly discovered long intergenic noncoding RNA (lincRNA), has been reported to be aberrantly expressed in various cancers, and may serve as a novel potential biomarker for cancer prognosis. This meta-analysis was conducted to investigate the effects of MALAT1 on cancer prognosis and lymph node metastasis. Methods: A quantitative meta-analysis was performed using a systematic search of PubMed, Medline and Web of Science databases to identify eligible papers on prognostic value of MALAT1 in cancers. The pooled hazard ratios (HRs) or odds ratios (OR) with a 95 % confidence interval (95 % Cl) were calculated to evaluate its prognostic value. Results: A total of 2094 patients from 17 studies between 2003 and 2016 were included. The results revealed that elevated MALAT1 expression was significantly associated with poor overall survival (OS) in 11 types of cancers (HR = 1.91, 95 % CI 1.49-2.34). Furthermore, subgroup analysis indicated that region of study (Germany, Japan or China), cancer type (digestive system cancers, urinary system cancers or respiratory system cancers) and sample size (more or less than 100) did not alter the significant predictive value of MALAT1 in OS from various types of cancer. In addition, upregulation of MALAT1 expression was significantly associated with poor disease-free survival (HR = 2.29, 95 % CI 1.24-3.35), and recurrence-free survival (HR = 2.09, 95 % CI 0.81-3.37). The results showed that the incidence of lymph node metastasis was higher in high MALAT1 expression group than that in low MALAT1 expression group (OR = 1.67, 95 % CI 1.30-2.15). Conclusions: This meta-analysis revealed that elevated MALAT1 expression may serve as a novel predictive biomarker for poor survival and lymph node metastasis in different types of cancer.
基金：
Nation Natural Science Foundation of ChinaNational Natural Science Foundation of China [81271007]
第一作者机构：[1]Sichuan Provincial Key Laboratory for Human Disease Gene Studyand Institute of Laboratory Medicine, Hospital of University of ElectronicScience and Technology of China and Sichuan Provincial People’s Hospital,Chengdu 610072, Sichuan, People’s Republic of China[3]Health Management Center, Hospital of Universityof Electronic Science and Technology of China and Sichuan Provincial People’sHospital, Chengdu 610072, Sichuan, People’s Republic of China
共同第一作者：
通讯作者：
通讯机构：[1]Sichuan Provincial Key Laboratory for Human Disease Gene Studyand Institute of Laboratory Medicine, Hospital of University of ElectronicScience and Technology of China and Sichuan Provincial People’s Hospital,Chengdu 610072, Sichuan, People’s Republic of China[2]Organ TransplantCentre, Hospital of University of Electronic Science and Technology of Chinaand Sichuan Provincial People’s Hospital, Chengdu 610072, Sichuan, People’sRepublic of China[3]Health Management Center, Hospital of Universityof Electronic Science and Technology of China and Sichuan Provincial People’sHospital, Chengdu 610072, Sichuan, People’s Republic of China[4]Schoolof Medicine, University of Electronic Science and Technology of China,Chengdu 610072, Sichuan, People’s Republic of China
推荐引用方式(GB/T 7714)：
Ping Shuai,Yu Zhou,Bo Gong,et al.Long noncoding RNA MALAT1 can serve as a valuable biomarker for prognosis and lymph node metastasis in various cancers: a meta-analysis[J].SPRINGERPLUS.2016,5:doi:10.1186/s40064-016-3342-7.
APA：
Ping Shuai,Yu Zhou,Bo Gong,Zhilin Jiang,Chong Yang...&Shikai Zhu.(2016).Long noncoding RNA MALAT1 can serve as a valuable biomarker for prognosis and lymph node metastasis in various cancers: a meta-analysis.SPRINGERPLUS,5,
MLA：
Ping Shuai,et al."Long noncoding RNA MALAT1 can serve as a valuable biomarker for prognosis and lymph node metastasis in various cancers: a meta-analysis".SPRINGERPLUS 5.(2016)
