机构：[1]The Hangzhou Xixi Hospital Affiliated to the Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310023, China.[2]Storr Liver Centre, Westmead Institute for Medical Research, the University of Sydney and Westmead Hospital, Westmead, NSW 2145, Australia.[3]The Fourth Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China.[4]The First Clinical Medical College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610075, China.[5]The Fourth Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China
出处：
ISSN：
摘要：
Hepatocellular carcinoma (HCC) is one of the most common malignancies and a major cause of cancer-related deaths. HCC often has an insidious onset, fast progression, and high tendency of metastasis and recurrence, hence it is a highly fatal malignant tumor. The origin of HCC is still a topic of debate but studies over the past decade have clearly identified liver cancer stem cells (LCSCs) being a cardinal source of liver cancer. LCSCs are a small subset of cells with the unlimited ability of self-renewal, differentiation, and uncontrollable growth. LCSCs are also resistant to conventional therapies and are thus believed to be responsible for treatment failure. Recent studies have indicated that long noncoding RNA (lncRNAs) may play important roles in the regulation of the biological functions of cancer stem cells (CSCs). The roles of lncRNAs on the biological properties of LCSCs are unknown. In this review, we briefly summarize the published studies on the functions and underlying mechanisms of commonly reported lncRNAs in the regulation of LCSCs.
基金：
Hangzhou Science and
Technology Bureau (grant number 20120533Q13) and
Zhejiang Medical and Health Science Research Fund
(grant number 2010KYA164).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|3 区医学
小类|3 区医学：研究与实验
最新[2023]版：
大类|4 区医学
小类|4 区医学：研究与实验
第一作者：
第一作者机构：[1]The Hangzhou Xixi Hospital Affiliated to the Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310023, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Cai Zhaobin,Xu Keyang,Li Yan,et al.Long noncoding RNA in liver cancer stem cells.[J].Discovery medicine.2017,24(131):87-93.
APA：
Cai Zhaobin,Xu Keyang,Li Yan,Lv Yuanlin,Bao Jianfeng&Qiao Liang.(2017).Long noncoding RNA in liver cancer stem cells..Discovery medicine,24,(131)
MLA：
Cai Zhaobin,et al."Long noncoding RNA in liver cancer stem cells.".Discovery medicine 24..131(2017):87-93
