机构：[1]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, China.四川大学华西医院[2]School of Pharmacy, Chengdu Medical College, Chengdu, Sichuan, China.[3]Institute of Digestive Surgery, Sichuan University, and Department of Gastrointestinal Surgery, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China.四川大学华西医院[4]Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.四川大学华西医院
Long noncoding RNA (lncRNA) plays a crucial role in the pathogenesis of various diseases, including colorectal cancer (CRC). The gene mutations of adenomatous polyposis coli (APC) were found in most patients with CRC. They function as important inducers of tumorigenesis. Based on our microarray results, we identified a specific upregulated lncRNA in CRC (SURC). Further analysis showed that high SURC expression correlated with poorer disease-free survival and overall survival in patients with CRC. Furthermore, we found that mutated APC genes can promote the transcription of SURC by reducing the degradation of β-catenin protein in CRC. Functional assays revealed that knockdown of SURC impaired CRC cell proliferation, colony formation, cell cycle, and tumor growth. Additionally, SURC promotes CCND2 expression by inhibiting the expression of miR-185-5p in CRC cells. In conclusion, we demonstrate that SURC is a specific upregulated lncRNA in CRC and the SURC/miR-185-5p/CCND2 axis may be targetable for CRC diagnosis and therapy.
基金：
This work was supported by grant 2020YJ0066 by the Basic Research for Application of
Sichuan Province, China program, grant 81972607 by the National Natural Science Foundation of China
Program, grant 2019HXBH033 of the Postdoctoral Research Project, West China Hospital of Sichuan
University, and grant ZYGD20003 of the 1.3.5 project for disciplines of excellence, West China Hospital
of Sichuan University.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类|1 区医学
小类|1 区医学：研究与实验
最新[2023]版：
大类|1 区医学
小类|1 区医学：研究与实验
第一作者：
第一作者机构：[1]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, China.
共同第一作者：
通讯作者：
通讯机构：[1]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, China.[*1]State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Ke Yuan Road 4, No. 1 Gao Peng Street, Chengdu, Sichuan Province 610041, People’s Republic of China.
推荐引用方式(GB/T 7714)：
Li Junshu,Ji Yanhong,Chen Na,et al.A specific upregulated long noncoding RNA in colorectal cancer promotes cancer progression[J].JCI insight.2022,7(15):doi:10.1172/jci.insight.158855.
APA：
Li Junshu,Ji Yanhong,Chen Na,Wang Huiling,Fang Chao...&Deng Hongxin.(2022).A specific upregulated long noncoding RNA in colorectal cancer promotes cancer progression.JCI insight,7,(15)
MLA：
Li Junshu,et al."A specific upregulated long noncoding RNA in colorectal cancer promotes cancer progression".JCI insight 7..15(2022)
医学