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Emerging role of RNA modification and long noncoding RNA interaction in cancer

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机构： [1]Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou 646000, China [2]Cell Therapy & Cell Drugs ofLuzhou Key Laboratory, Luzhou 646000, China [3]South Sichuan Institute of Translational Medicine, Luzhou 646000, China [4]Department of Oncology, The Affiliated Hospital ofSouthwest Medical University, Luzhou 646000, China

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RNA modification, especially N6-methyladenosine, 5-methylcytosine, and N7-methylguanosine methylation, participates in the occurrence and progression of cancer through multiple pathways. The function and expression of these epigenetic regulators have gradually become a hot topic in cancer research. Mutation and regulation of noncoding RNA, especially lncRNA, play a major role in cancer. Generally, lncRNAs exert tumor-suppressive or oncogenic functions and its dysregulation can promote tumor occurrence and metastasis. In this review, we summarize N6-methyladenosine, 5-methylcytosine, and N7-methylguanosine modifications in lncRNAs. Furthermore, we discuss the relationship between epigenetic RNA modification and lncRNA interaction and cancer progression in various cancers. Therefore, this review gives a comprehensive understanding of the mechanisms by which RNA modification affects the progression of various cancers by regulating lncRNAs, which may shed new light on cancer research and provide new insights into cancer therapy.© 2024. The Author(s).

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大类 | 3 区医学

小类 | 2 区生物工程与应用微生物 3 区遗传学 3 区医学：研究与实验 4 区肿瘤学

第一作者：

第一作者机构： [1]Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou 646000, China [2]Cell Therapy & Cell Drugs ofLuzhou Key Laboratory, Luzhou 646000, China [3]South Sichuan Institute of Translational Medicine, Luzhou 646000, China

通讯作者：

通讯机构： [1]Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou 646000, China [2]Cell Therapy & Cell Drugs ofLuzhou Key Laboratory, Luzhou 646000, China [3]South Sichuan Institute of Translational Medicine, Luzhou 646000, China

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