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MicroRNA-1288 promotes cell proliferation of human glioblastoma cells by repressing ubiquitin carboxyl-terminal hydrolase CYLD expression

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收录情况： ◇ SCIE

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机构： [1]Department of Radiation Oncology, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610041 [2]Department of Oncology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180 [3]Department of Craniofacial and Neurosurgery, Sichuan Cancer Hospital, Chengdu, Sichuan 610041 [4]Department of Neurosurgery, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China

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关键词： microRNA-1288 glioblastoma ubiquitin carboxyl-terminal hydrolase CYLD cell proliferation

摘要：

Previous studies have demonstrated that microRNAs (miRs) are important regulators involved in various cancers, including human glioblastoma (GBM). However, the underlying mechanism of miR-1288 remains poorly understood, and its role in GBM has not been reported. The present study confirmed that miR-1288 expression was markedly up-regulated in GBM. Ectopic expression of miR-1288 promoted the prolife-ration, colony formation and anchorage-independent growth of GBM cells. Bioinformatics analysis coupled with western blotting and luciferase report assays also indicated that miR-1288 promoted cell proliferation of GBM by targeting ubiquitin carboxyl-terminal hydrolase (CYLD). Knockdown of CYLD expression reversed the cell proliferation promotion by miR-1288-in in GBM. These results suggest that the miR-1288/CYLD axis may represent a potential therapeutic target for the treatment of GBM.

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出版当年[2017]版：

大类 | 4 区医学

小类 | 4 区医学：研究与实验 4 区肿瘤学

最新[2023]版：

大类 | 3 区医学

小类 | 4 区医学：研究与实验 4 区肿瘤学

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出版当年[2017]版：

Q3 MEDICINE, RESEARCH & EXPERIMENTAL Q4 ONCOLOGY

最新[2023]版：

Q2 MEDICINE, RESEARCH & EXPERIMENTAL Q2 ONCOLOGY

影响因子： 3.4 最新[2023版] 3 最新五年平均 1.922 出版当年[2017版] 1.912 出版当年五年平均 1.692 出版前一年[2016版] 1.851 出版后一年[2018版]

第一作者：

第一作者机构： [1]Department of Radiation Oncology, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610041 [*1]Department of Radiation Oncology, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, 55 Renmin South Road, Chengdu, Sichuan 610041, P.R. China

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通讯作者：

通讯机构： [1]Department of Radiation Oncology, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610041 [*1]Department of Radiation Oncology, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, 55 Renmin South Road, Chengdu, Sichuan 610041, P.R. China

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