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Deubiquitinating enzyme USP41 promotes lung cancer cell proliferation and migration.

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收录情况： ◇ SCIE

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机构： [1]Department of Pulmonary and Critical Care Medicine, Sichuan Academy of Medical Sciences & Sichuan Province People’s Hospital, Chengdu, China [2]Department of Anesthesiology, Huashan Hospital Affiliated to Fudan University, Shanghai, China [3]Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, China [4]Key Laboratory of Post-Neuroinjury Neurorepair and Regeneration in Central Nervous System, Ministry of Education, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China

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关键词： deubiquitylating enzyme invasion migration non-small cell lung cancer USP41

摘要：

To reveal the function of deubiquitylating enzyme USP41 in lung adenocarcinoma. The relationship between USP41 and lung cancer was determined by analyzing data from The Cancer Genome Atlas (TCGA). A549 and H1299 cell lines were transfected with short hairpin RNA against USP41 (shUSP41 group) or negative control (shCon group). Western blotting was used to verify the transfection efficacy and marker expression. Cell proliferation and apoptosis were analyzed by EdU assay, MTT assay, and flow cytometry after USP41 knockdown. Transwell assay was used to determine the effect of USP41 downregulation on cell migration. Analysis of lung cancer data from TCGA database indicated a higher level of USP41 expression in lung cancer tumor tissue compared with that in noncancerous tissue, and USP41 overexpression was correlated with poor overall survival of lung cancer patients (p < 0.01). The outcomes of the EdU, MTT, and flow cytometry assays indicated decreased cell proliferation and enhanced apoptosis in shUSP41-transfected cells. Transwell assay further demonstrated that USP41 knockdown increased the migration rate of A549 and H1299 cells. In our study, USP41 was overexpressed in lung cancer tissue and associated with poor prognosis of lung cancer. USP41 knockdown inhibits cell proliferation and migration and induces cell apoptosis of lung cancer. © 2021 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.

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出版当年[2021]版：

大类 | 3 区医学

小类 | 3 区肿瘤学 3 区呼吸系统

最新[2023]版：

大类 | 3 区医学

小类 | 4 区肿瘤学 4 区呼吸系统

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出版当年[2021]版：

Q3 ONCOLOGY Q3 RESPIRATORY SYSTEM

最新[2023]版：

Q2 RESPIRATORY SYSTEM Q3 ONCOLOGY

影响因子： 2.3 最新[2023版] 2.8 最新五年平均 3.223 出版当年[2021版] 3.197 出版当年五年平均 3.5 出版前一年[2020版] 2.9 出版后一年[2022版]

第一作者：

第一作者机构： [1]Department of Pulmonary and Critical Care Medicine, Sichuan Academy of Medical Sciences & Sichuan Province People’s Hospital, Chengdu, China

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通讯作者：

通讯机构： [3]Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, China [4]Key Laboratory of Post-Neuroinjury Neurorepair and Regeneration in Central Nervous System, Ministry of Education, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China [*1]Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, China

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Deubiquitinating enzyme USP41 promotes lung cancer cell proliferation and migration.

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