机构：[1]Department of Anorectal Surgery, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, China四川省人民医院[2]Department of Dermatology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China四川大学华西医院[3]Institute of Dermatology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, China四川省人民医院
Keloids are benign dermal fibroproliferative tumors that develop as a result of several dysregulated processes. Emerging evidence has revealed that miRNAs contribute to keloid formation. However, the molecular mechanisms of keloid pathogenesis remain unclear. In our study, we found that miR-141-3p in keloid tissues and keloid fibroblasts was significantly decreased compared with the levels in normal tissues and normal skin fibroblasts, respectively. miR-141-3p overexpression resulted in significantly decreased proliferation and migration and the promotion of apoptosis in keloid fibroblasts, whereas miR141-3p knockdown in keloid fibroblasts yielded the opposite results. Growth factor receptor binding 2 associated binding protein 1 (GAB1) was identified and confirmed as a direct target of miR-141-3p. The expression of GAB1 was up-regulated in keloid tissues, and the restoration of GAB1 partially reversed the inhibitory effects of miR-141-3p on the proliferation and migration of keloid fibroblasts. All data suggested that miR-141-3p decreased the proliferation and migration of keloid fibroblasts by repressing GAB1 expression, providing a useful target for keloid management. (C) 2017 Elsevier Inc. All rights reserved.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81101231]
第一作者机构：[1]Department of Anorectal Surgery, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, China
共同第一作者：
通讯作者：
通讯机构：[3]Institute of Dermatology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, China[*1]Institute of Dermatology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, No. 32, Western 2nd Section, 1st Ring Road, Chengdu, Sichuan, China
推荐引用方式(GB/T 7714)：
Feng Jingjuan,Xue Siliang,Pang Qiuyu,et al.miR-141-3p inhibits fibroblast proliferation and migration by targeting GAB1 in keloids[J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2017,490(2):302-308.doi:10.1016/j.bbrc.2017.06.040.
APA：
Feng, Jingjuan,Xue, Siliang,Pang, Qiuyu,Rang, Zhen&Cui, Fan.(2017).miR-141-3p inhibits fibroblast proliferation and migration by targeting GAB1 in keloids.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,490,(2)
MLA：
Feng, Jingjuan,et al."miR-141-3p inhibits fibroblast proliferation and migration by targeting GAB1 in keloids".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 490..2(2017):302-308
