详情页 - 四川省肿瘤医院知识库

当前位置：首页 > 详情页

NEDD1 Promotes the Development of Lung Adenocarcinoma and Can be Used as a Prognostic Marker

文献详情

资源类型：

Pubmed体系：

作者：

机构： [1]Key Laboratory of Tumor Molecular Biology in Binzhou Medical University, Department of Biochemistry and Molecular Biology, Binzhou Medical University, Yantai, Shandong 264003, China. [2]Institute of Healthcare and Industry, Sichuan Tourism College, Chengdu, Sichuan 610000, China. [3]Jining Medical University, Jining, Shandong 272067, China. [4]Yantai Center for Disease Control and Prevention, Yantai, Shandong 264003, China. [5]Department of Cardiology, Zhaoyuan people's Hospital, Yantai, Shandong 265499, China. [6]Department of Gastrointestinal Surgery, Yuhuangding Hospital, Yantai, Shandong 265499, China. [7]Department of Burn and Plastic Surgery, Yantai Affiliated Hospital of Binzhou Medical University, Shandong, China.

出处：

DOI：

ISSN：

关键词： NEDD1 lung cancer migration proliferation

摘要：

Objective : To explore the roles of Neural precursor cell expressed developmentally down-regulated 1(NEDD1) in lung cancer tumorigenesis and the relationship between NEDD1 expression and clinicopathology of patients with lung adenocarcinoma (LUAD). Methods: Expression of NEDD1 or other proteins in tissues and cell lines were determined with immunohistochemistry or western blot, the data of patients with LUAD in The Cancer Genome Atlas (TCGA) datasets and LUAD tissue array were collected and analyzed, the effects of NEDD1 on proliferation, migration, cell cycle progression and apoptosis of cancer cells were detected with colony formation assay, transwell assay and Flow cytometry (FCM) analysis respectively. the impact of NEDD1 knockdown on DNA damage was analyzed using Immunofluorescence staining of H2AX and comet assay. Furthermore, the effect of NEDD1 on cancer cell proliferation in vivo was investigated in nude mice. Results : NEDD1 was upregulated in lung tissues and the NEDD1 immune score was an independent prognostic factor. Overexpression of NEDD1 promoted epithelial-mesenchymal transition, accelerated cell cycle progression, and enhanced the proliferation and migration of A549 and H1299 cells, while knockdown of NEDD1 resulted in the opposite phenotype and leaded to DNA damage. In addition, NEDD1 improved cell tumorigenicity in vivo. Conclusion : These findings suggest that NEDD1 plays important roles in lung cancer development and may therefore be a potential prognostic marker and promising therapeutic target for lung cancer therapy.© The author(s).

基金：

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2023]版：

大类 | 3 区医学

小类 | 4 区肿瘤学

最新[2023]版：

大类 | 3 区医学

小类 | 4 区肿瘤学

第一作者：

第一作者机构： [1]Key Laboratory of Tumor Molecular Biology in Binzhou Medical University, Department of Biochemistry and Molecular Biology, Binzhou Medical University, Yantai, Shandong 264003, China. [2]Institute of Healthcare and Industry, Sichuan Tourism College, Chengdu, Sichuan 610000, China.

共同第一作者：

通讯作者：

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]Deubiquitinating enzyme USP41 promotes lung cancer cell proliferation and migration. [2]FL118 inhibits proliferation, migration, invasion, while promoting apoptosis in non-small cell lung cancer [3]HOXC-AS2 mediates the proliferation, apoptosis, and migration of non-small cell lung cancer by combining with HOXC13 gene [4]MiR-142-5p Suppresses Tumorigenesis by Targeting PIK3CA in Non-Small Cell Lung Cancer [5]Knockdown of HJURP inhibits non-small cell lung cancer cell proliferation, migration, and invasion by repressing Wnt/beta-catenin signaling [6]槲皮素对人肝癌细胞生长、迁移能力的影响及机制研究 [7]IDH1 mutation promotes proliferation and migration of glioma cells via EMT induction [8]miRNA-9 Inhibits Proliferation and Migration of Lung Squamous Cell Carcinoma Cells by Regulating NRSF/EGFR [9]miR-141-3p inhibits fibroblast proliferation and migration by targeting GAB1 in keloids [10]紫花前胡素通过PI3K/Akt信号通路影响结直肠癌细胞增殖、凋亡及迁移