机构：[1]Department of Gynecological Radiotherapy, Harbin Medical University Cancer Hospital, No. 150 Haping Road, Nangang District, Harbin 150081, Heilongjiang, China[2]Department of Radiotherapy, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, No. 55 Renmin South Road, Chengdu 610041, Sichuan, China四川省人民医院四川省肿瘤医院[3]Pharmacy Department, Sichuan Jinxin Women and Children’s Hospital, No. 66 Jingxiu Road, Jinjiang District, Chengdu 610061, Sichuan, China.
Recently, extensive evidence has clarified the crucial role of circular RNAs (circRNAs) as a pro-tumor or anti-cancer participant in human malignancies. A new circRNA derived from oxysterol binding protein like 10 (OSBPL10) (circOSBPL10) has not been researched in cervical cancer (CC) yet.The expression of molecules was analyzed by RT-qPCR or western blot. Several functional assays were applied to explore the biological influence of circOSBPL10 on CC. The interaction between RNAs was estimated via luciferase reporter, RNA immunoprecipitation and RNA pull-down assays.CircOSBPL10 characterized with cyclic structure was revealed to possess elevated expression in CC cells. CircOSBPL10 downregulation elicited suppressive impacts on CC cell proliferation and migration. Interestingly, circOSBPL10 regulated CC progression by interacting with microRNA-1179 (miR-1179). Moreover, ubiquitin conjugating enzyme E2 Q1 (UBE2Q1) targeted by miR-1179 was positively regulated by circOSBPL10 in CC. Furthermore, enhanced UBE2Q1 expression or suppressed miR-1179 level countervailed the repressive effect of circOSBPL10 depletion on the malignant phenotypes of CC cells. Moreover, forkhead box A1 (FOXA1) was confirmed to induce circOSBPL10 expression in CC cells.FOXA1-induced circOSBPL10 facilitates CC progression through miR-1179/UBE2Q1 axis, highlighting a strong potential for circOSBPL10 to serve as a promising therapeutic target in CC.
基金：
National Natural Science Foundation of China (81872460), The National Cancer Center Climbing Foundation of China(NCC201808B016), Department of Science and Technology of Sichuan Province(20YYJC3815), Department of Science and Technology of Sichuan Province(20GJHZ0088).
第一作者机构：[1]Department of Gynecological Radiotherapy, Harbin Medical University Cancer Hospital, No. 150 Haping Road, Nangang District, Harbin 150081, Heilongjiang, China
通讯作者：
通讯机构：[2]Department of Radiotherapy, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, No. 55 Renmin South Road, Chengdu 610041, Sichuan, China[3]Pharmacy Department, Sichuan Jinxin Women and Children’s Hospital, No. 66 Jingxiu Road, Jinjiang District, Chengdu 610061, Sichuan, China.
推荐引用方式(GB/T 7714)：
Shanshan Yang,Yiwen Jiang,Xiaoli Ren,et al.FOXA1-induced circOSBPL10 potentiates cervical cancer cell proliferation and migration through miR-1179/UBE2Q1 axis.[J].CANCER CELL INTERNATIONAL.2020,20(1):doi:10.1186/s12935-020-01360-2.
APA：
Shanshan Yang,Yiwen Jiang,Xiaoli Ren,Dan Feng,Liaoyun Zhang...&Shun Lu.(2020).FOXA1-induced circOSBPL10 potentiates cervical cancer cell proliferation and migration through miR-1179/UBE2Q1 axis..CANCER CELL INTERNATIONAL,20,(1)
MLA：
Shanshan Yang,et al."FOXA1-induced circOSBPL10 potentiates cervical cancer cell proliferation and migration through miR-1179/UBE2Q1 axis.".CANCER CELL INTERNATIONAL 20..1(2020)
