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SQLE induces epithelial-to-mesenchymal transition by regulating of miR-133b in esophageal squamous cell carcinoma

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收录情况： ◇ SCIE ◇ 统计源期刊 ◇ CSCD-C

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机构： [1]Department of Gastroenterology, First People’s Hospital of Yancheng City, Yancheng 224001, China, [2]Department of Oncology, Jimin Hospital, Shanghai 200052, China, [3]College of Nursing, Yancheng Vocational Institute of Health Sciences, Yancheng 224006, China [4]Sichuan Cancer Hospital, Chengdu 610041, China

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关键词： esophageal squamous cell carcinoma miR-133b SQLE epithelial-to-mesenchymal transition

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Increasing evidence suggests that microRNAs, which control gene expression at the post-transcriptional level, are aberrantly expressed in cancers and play significant roles in carcinogenesis and cancer progression. In this study, we show differential miR-133b down-expression in human esophageal squamous cell carcinoma (ESCC) cells and tissues. In addition, squalene epoxidase (SQLE), a key enzyme of cholesterol synthesis, is identified as the direct downstream target gene of miR-133b by luciferase gene reporter assay. Furthermore, ectogenic miR-133b expression and SQLE knockdown can inhibit proliferation, invasion, and metastasis, and diminish epithelial-to- mesenchymal transition (EMT) traits of ESCC in vitro, implying that miR-133b-dependent SQLE can induce tumorigenicity and that SQLE is an EMT inducer. Xenograft experiment results also proved the biological function of SQLE in vivo. Therefore, we conclude that miR-133b-dependent SQLE plays a critical role in the potential metastasis mechanisms in ESCC.

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出版当年[2017]版：

大类 | 3 区生物

小类 | 4 区生化与分子生物学 4 区生物物理

最新[2025]版：

大类 | 2 区生物学

小类 | 2 区生化与分子生物学 2 区生物物理

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出版当年[2017]版：

Q3 BIOPHYSICS Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

最新[2023]版：

Q1 BIOPHYSICS Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

影响因子： 3.3 最新[2023版] 3.4 最新五年平均 2.224 出版当年[2017版] 2.293 出版当年五年平均 2.2 出版前一年[2016版] 2.502 出版后一年[2018版]

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第一作者机构： [1]Department of Gastroenterology, First People’s Hospital of Yancheng City, Yancheng 224001, China,

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