Bone marrow involvement in neuroblastoma indicates an advanced stage of the disease. In this study, we retrospectively analyzed the bone marrow infiltration status and hematological parameters of 111 cases of neuroblastoma. Among the 111 cases, 62 (55.9%) exhibited marrow infiltration. Erythrocytopenia, anemia, and thrombocytopenia were significantly (p<0.05) associated with marrow infiltration of >10% malignant cells. The evaluation of blood cell count parameters with receiver operating characteristic curves indicated that erythrocytopenia can substantially improve the accurate prediction of the risk of bone marrow involvement with a Youden index of 0.60. The sensitivity and specificity were 90% and 70%, respectively, which correspond to a cut-off value of 4.015x10 boolean AND 12/L. Hematological aspects with diagnostic value are different among neuroblastoma patients with and without bone marrow infiltration.
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外文
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出版当年[2017]版：
大类|4 区医学
小类|4 区医学实验技术
最新[2023]版：
大类|4 区医学
小类|4 区医学实验技术
第一作者：
第一作者机构：[1]Sun Yat Sen Univ, Ctr Canc, Dept Hematol Oncol, 651 Dongfengdong Rd, Guangzhou 510065, Guangdong, Peoples R China;
通讯作者：
通讯机构：[1]Sun Yat Sen Univ, Ctr Canc, Dept Hematol Oncol, 651 Dongfengdong Rd, Guangzhou 510065, Guangdong, Peoples R China;[6]State Key Lab Oncol South China, Guangzhou, Guangdong, Peoples R China;[7]Collaborat Innovat Ctr Canc Med, Guangzhou, Guangdong, Peoples R China
推荐引用方式(GB/T 7714)：
Wang Weida,Peng Xiongwen,Liang Cuirong,et al.Comparison of Hematological Aspects between Neuroblastoma Patients with and without Bone Marrow Infiltration[J].ANNALS OF CLINICAL AND LABORATORY SCIENCE.2017,47(4):416-421.
APA：
Wang, Weida,Peng, Xiongwen,Liang, Cuirong,Chen, Hao,Zhang, Yingchun...&Lu, Yue.(2017).Comparison of Hematological Aspects between Neuroblastoma Patients with and without Bone Marrow Infiltration.ANNALS OF CLINICAL AND LABORATORY SCIENCE,47,(4)
MLA：
Wang, Weida,et al."Comparison of Hematological Aspects between Neuroblastoma Patients with and without Bone Marrow Infiltration".ANNALS OF CLINICAL AND LABORATORY SCIENCE 47..4(2017):416-421
