机构：[1]Tissue and Tumor Microenvironments Group, Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, United Kingdom.[2]Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.[3]Centre for Osteoarthritis Pathogenesis Versus Arthritis, Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, United Kingdom.
The bone marrow (BM) vascular niche microenvironments harbor stem and progenitor cells of various lineages. Bone angiogenesis is distinct and involves tissue-specific signals. The nurturing vascular niches in the BM are complex and heterogenous consisting of distinct vascular and perivascular cell types that provide crucial signals for the maintenance of stem and progenitor cells. Growing evidence suggests that the BM niche is highly sensitive to stress. Aging, inflammation and other stress factors induce changes in BM niche cells and their crosstalk with tissue cells leading to perturbed hematopoiesis, bone angiogenesis and bone formation. Defining vascular niche remodeling under stress conditions will improve our understanding of the BM vascular niche and its role in homeostasis and disease. Therefore, this review provides an overview of the current understanding of the BM vascular niches for hematopoietic stem cells and their malfunction during aging, bone loss diseases, arthritis and metastasis.
基金：
Medical Research Council (CDA:
MR/P02209X/1), European Research Council (StG: metaNiche,
805201), Leuka (2017/JGF/001), The Royal Society (RG170326),
Kennedy Trust for Rheumatology Research (KENN 15 16 09),
and John Fell Fund OUP Research Fund (161/061). FW is a
UKRI Future Leaders Fellow (S016538) and a member of the
Centre for Osteoarthritis Pathogenesis Versus Arthritis (grants
20205 and 21621). She was supported by the NIHR Oxford
Biomedical Research Centre. The views expressed are those of the
authors and not necessarily those of the NHS, the NIHR or the
Department of Health.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类|2 区生物学
小类|2 区发育生物学3 区细胞生物学
最新[2023]版：
大类|2 区生物学
小类|2 区发育生物学3 区细胞生物学
第一作者：
第一作者机构：[1]Tissue and Tumor Microenvironments Group, Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, United Kingdom.
通讯作者：
通讯机构：[1]Tissue and Tumor Microenvironments Group, Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, United Kingdom.[3]Centre for Osteoarthritis Pathogenesis Versus Arthritis, Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, United Kingdom.
推荐引用方式(GB/T 7714)：
Stucker Sina,Chen Junyu,Watt Fiona E,et al.Bone Angiogenesis and Vascular Niche Remodeling in Stress, Aging, and Diseases.[J].Frontiers in cell and developmental biology.2020,8:602269.doi:10.3389/fcell.2020.602269.
APA：
Stucker Sina,Chen Junyu,Watt Fiona E&Kusumbe Anjali P.(2020).Bone Angiogenesis and Vascular Niche Remodeling in Stress, Aging, and Diseases..Frontiers in cell and developmental biology,8,
MLA：
Stucker Sina,et al."Bone Angiogenesis and Vascular Niche Remodeling in Stress, Aging, and Diseases.".Frontiers in cell and developmental biology 8.(2020):602269
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