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LncRNA TP73-AS1 accelerates tumor progression in gastric cancer through regulating miR-194-5p/SDAD1 axis

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机构： [1]Gastrointestinal center, Sichuan Cancer Hospital & Institute, Chengdu, 610041, China [2]Oncology Center, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu, 610072, China [3]Department of Gastrointestinal Surgery, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu, 610072, China

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关键词： TP73-AS1 miR-194-5 SDAD1 Proliferation Gastric cancer

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Background: Long noncoding RNAs (lncRNAs) have been considered as significant regulators in many cancer progression, such as proliferation, invasion and other path of evolution. Nevertheless, we have not had a grasp of the role of lncRNA TP73-AS1 in gastric cancer (GC). Methods: qRT-PCR analysis was first conducted to examine the TP73-AS1 level in both GC tissues and cell lines. Then gain or loss-of-function assays were carried out to detect the effect of TP73-AS1 on GC development. In mechanism, bioinformatics analysis and luciferase reporter assays were used to search and confirm the target gene of TP73-AS1. Finally, rescue assays were performed to confirm the influence of TP73-AS1-miR-194-5p-SDAD1 axis on GC development. Results: TP73-AS1 was upregulated in GC tissues and cell lines. Furthermore, TP73-AS1 exerted oncogenic role in GC through promoting cell growth and metastasis. In addition, TP73-AS1 was certified as a ceRNA by regulating miR-194-5p/SDAD1 axis. Conclusions: TP73-AS1 accelerates tumor progression in gastric cancer through regulating miR-194-5p/SDAD1 axis.

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出版当年[2018]版：

大类 | 4 区医学

小类 | 4 区病理学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区病理学

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出版当年[2018]版：

Q3 PATHOLOGY

最新[2023]版：

Q2 PATHOLOGY

影响因子： 2.9 最新[2023版] 2.6 最新五年平均 1.794 出版当年[2018版] 1.635 出版当年五年平均 1.466 出版前一年[2017版] 2.05 出版后一年[2019版]

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第一作者机构： [1]Gastrointestinal center, Sichuan Cancer Hospital & Institute, Chengdu, 610041, China

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