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Transarterial chemoembolisation for breast cancer with liver metastasis: A systematic review

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机构: [1]Southern Med Univ, Sch Clin Med 2, Zhujiang Hosp, Dept Gen Surg, 253 Ind Ave, Guangzhou 510282, Guangdong, Peoples R China; [2]Sun Yat Sen Univ, Ctr Canc, Breast Surg Dept, 651 Dongfeng East Rd, Guangzhou 510060, Guangdong, Peoples R China
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关键词: Breast cancer with liver metastasis Transarterial chemoembolisation

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Background: There is limited data on the impact of transarterial chemoembolisation (TACE) on survival in patients of breast cancer with liver metastasis (BCLM). Methods: A systematic review was conducted to assess TACE effect on BCLM patients. A search for clinical studies published since 1/1/2000 to 1/1/2017 was performed. Survival data from all studies were extracted to evaluate the efficacy of TACE, including overall survival, disease free survival and response rate. Toxic side effects data were also extracted to assess the safety of TACE. Results: A total of 10 studies with 519 BCLM patients were identified. 78.0% patients were treated with TACE, 9.9% were treated with TACE plus systematic chemotherapy and 12.1% were treated with systematic chemotherapy alone. Pooled median overall survival of patients who received TACE ranged from 7.3 to 47.0 months, median disease free survival ranged from 2.9 to 17.0 months and response rates ranged from 7.0 to 73.5%. Pooled Grade 3 and 4 side effects (blood toxicities, liver toxicity and post-embolization syndrome) ranged from 0.0 to 17.4%. Conclusions: TACE is one of an effective treatment for BCLM and whether a specific patient is appropriate to receive TACE depends on a multiple disciplinary team discussion. (C) 2017 Published by Elsevier Ltd.

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出版当年[2017]版:
大类 | 3 区 医学
小类 | 2 区 妇产科学 4 区 肿瘤学
最新[2023]版:
大类 | 2 区 医学
小类 | 2 区 妇产科学 3 区 肿瘤学
第一作者:
第一作者机构: [1]Southern Med Univ, Sch Clin Med 2, Zhujiang Hosp, Dept Gen Surg, 253 Ind Ave, Guangzhou 510282, Guangdong, Peoples R China;
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通讯机构: [1]Southern Med Univ, Sch Clin Med 2, Zhujiang Hosp, Dept Gen Surg, 253 Ind Ave, Guangzhou 510282, Guangdong, Peoples R China;
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