机构:[1]Koo Fdn Sun Yat Sen Canc Ctr, Div Gastroenterol & Hepatobiliary Dis, Dept Med, Taipei, Taiwan;临床科室肝胆胰科中山大学肿瘤防治中心[2]Koo Fdn Sun Yat Sen Canc Ctr, Dept Res, Taipei, Taiwan;中山大学肿瘤防治中心[3]Koo Fdn Sun Yat Sen Canc Ctr, 125 Lih Der Rd, Taipei 11259, Taiwan中山大学肿瘤防治中心
Background: In patients with lung metastasis of hepatocellular carcinoma (HCC), it remains uncertain how a better survival outcome can be predicted after metastasectomy. This study aims to identify clinical factors that may be used to guide patient selection for such a therapeutic modality. A total of 28 patients who received pulmonary metastasectomy for HCC between 1993 and 2012 were identified. All relevant clinical factors were extracted from medical records up to September 2015. Patients were classified into high- and low-risk groups according to survival outcome after metastasectomy. All pertinent clinical factors were analyzed for correlation with survival outcome. Summary: The overall survival of 28 patients after pulmonary metastasectomy was studied first. The survival curve was biphasic and reached a plateau at 40 months after metastasectomy. The results indicate the presence of 2 groups of patients with a different survival outcome. Among all clinical parameters, remission status in the liver before pulmonary metastasectomy and distant metastasis-free interval between the last treatment of HCC and the occurrence of lung metastasis were found to be significantly associated with excellent survival outcome after pulmonary metastasectomy (p = 0.019 and 0.007 by Fisher exact test, and p = 0.002 and 0.0002 by Cox regression analysis). (C) 2017 S. Karger AG, Basel
基金:
Institution Review Board of Koo Foundation Sun Yat-Sen Cancer Center [20160222A]
语种:
外文
被引次数:
WOS:
中科院(CAS)分区:
出版当年[2017]版:
大类|1 区医学
小类|2 区胃肠肝病学2 区肿瘤学
最新[2023]版:
大类|1 区医学
小类|1 区胃肠肝病学1 区肿瘤学
第一作者:
第一作者机构:[1]Koo Fdn Sun Yat Sen Canc Ctr, Div Gastroenterol & Hepatobiliary Dis, Dept Med, Taipei, Taiwan;
通讯作者:
通讯机构:[1]Koo Fdn Sun Yat Sen Canc Ctr, Div Gastroenterol & Hepatobiliary Dis, Dept Med, Taipei, Taiwan;[3]Koo Fdn Sun Yat Sen Canc Ctr, 125 Lih Der Rd, Taipei 11259, Taiwan
推荐引用方式(GB/T 7714):
Kuo Tse-Ming,Chang Kai-Ming,Cheng Tsun-I,et al.Clinical Factors Predicting Better Survival Outcome for Pulmonary Metastasectomy of Hepatocellular Carcinoma[J].LIVER CANCER.2017,6(4):297-306.doi:10.1159/000477134.
APA:
Kuo, Tse-Ming,Chang, Kai-Ming,Cheng, Tsun-I&Kao, Kuo-Jang.(2017).Clinical Factors Predicting Better Survival Outcome for Pulmonary Metastasectomy of Hepatocellular Carcinoma.LIVER CANCER,6,(4)
MLA:
Kuo, Tse-Ming,et al."Clinical Factors Predicting Better Survival Outcome for Pulmonary Metastasectomy of Hepatocellular Carcinoma".LIVER CANCER 6..4(2017):297-306