机构：[1]The Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China[2]The Department of Gastrointestinal Surgery, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, People’s Republic of China[3]Institute of Hepatobiliary, Pancreatic and Intestinal Disease, North Sichuan Medical College, Nanchong, Sichuan, People’s Republic of China[4]The Department of Pathology, North Sichuan Medical College, Nanchong, Sichuan, People’s Republic of China[5]The Department of Medical Microbiology and Parasitology, North Sichuan Medical College, Nanchong, Sichuan, People’s Republic of China
MicroRNAs have recently emerged as regulators of many biological processes including cell proliferation, development and differentiation. This study identified that miR-22 was statistically decreased in colorectal cancer clinical specimens and highly metastatic cell lines. Moreover, low miR-22 expression was associated with tumor metastasis, advanced clinical stage and relapse. Consistent with clinical observations, miR-22 significantly suppressed the ability of colorectal cancer cells to growth and metastasize in vitro and in vivo. Sp1 was validated as a target of miR-22, and ectopic expression of Sp1 compromised the inhibitory effects of miR-22. In addition, Sp1 repressed miR-22 transcription by binding to the miR-22 promoter, hence forming a negative feedback loop. Further study has shown that miR-22 suppresses the activity of PTEN/AKT pathway by Sp1. Our present results implicate the newly indentified miR-22/Sp1/PTEN/AKT axis might represent a potential therapeutic target for colorectal cancer.
基金：
Scientific Research Project of Sichuan Medical Association [S15024]; Sichuan Youth Science and Technology Foundation [2017JQ0039]; Scientific Research Project of Nanchong Municipal Science and Technology Bureau [16YFZJ0128]; Scientific Research Project of Sichuan Provincial Health and Family Planning Commission [16ZD037]; Scientific Research Fund of Sichuan Provincial Education Department of China [14ZA0184, 13ZA0230]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|2 区医学
小类|2 区肿瘤学3 区细胞生物学
最新[2023]版：
无
第一作者：
第一作者机构：[1]The Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China
共同第一作者：
通讯作者：
通讯机构：[1]The Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China[2]The Department of Gastrointestinal Surgery, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, People’s Republic of China[3]Institute of Hepatobiliary, Pancreatic and Intestinal Disease, North Sichuan Medical College, Nanchong, Sichuan, People’s Republic of China
推荐引用方式(GB/T 7714)：
Xia Shu-Sen,Zhang Guang-Jun,Liu Zuo-Liang,et al.MicroRNA-22 suppresses the growth, migration and invasion of colorectal cancer cells through a Sp1 negative feedback loop.[J].Oncotarget.2017,8(22):36266-36278.doi:10.18632/oncotarget.16742.
APA：
Xia, Shu-Sen,Zhang, Guang-Jun,Liu, Zuo-Liang,Tian, Hong-Peng,He, Yi...&Zhou, Tong.(2017).MicroRNA-22 suppresses the growth, migration and invasion of colorectal cancer cells through a Sp1 negative feedback loop..Oncotarget,8,(22)
MLA：
Xia, Shu-Sen,et al."MicroRNA-22 suppresses the growth, migration and invasion of colorectal cancer cells through a Sp1 negative feedback loop.".Oncotarget 8..22(2017):36266-36278
