Urolithin families are gut-microbial metabolites of ellagic acid (EA). Although urolithin A (UA) and urolithin B (UB) were reported to have antiproliferative activities in cancer cells, the role and related mechanisms of urolithin C (UC) in colorectal cancer (CRC) have not yet been clarified. In this study, we assess the antitumor activities of UC in vitro and in vivo and further explore the underlying mechanisms in CRC cell lines. We found that UC inhibited the proliferation and migration of CRC cells, induced apoptosis, and arrested the cell cycle at the G2/M phase in vitro, and UC inhibited tumor growth in a subcutaneous transplantation tumor model in vivo. Mechanically, UC blocked the activation of the AKT/mTOR signaling pathway by decreasing the expression of Y-box binding protein 1(YBX1). The AKT agonist SC79 could reverse the suppression of cell proliferation in UC-treated CRC cells. In conclusion, our research revealed that UC could prevent the progression of CRC by blocking AKT/mTOR signaling, suggesting that it may have potential therapeutic values.
基金：
This work was supported by the grants from the National
Key R&D Program of China [grant number 2023YFC3402100];
the National Natural Science Foundation of China (grant number
92259102, 82203331, 82300137); Natural Science Foundation of
Sichuan (grant number 24NSFSC0057, 24NSFSC1698); Natural
Science Foundation of Chongqing (grant number CSTB2023NS
CQ-MSX0065)
第一作者机构：[1]Chengdu Univ Tradit Chinese Med, Sch Med & Life Sci, Chengdu 611137, Peoples R China
通讯作者：
通讯机构：[1]Chengdu Univ Tradit Chinese Med, Sch Med & Life Sci, Chengdu 611137, Peoples R China[2]Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Dept Oncol, Chengdu 610072, Peoples R China[3]Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Canc Inst, Sichuan Acad Med Sci, Chengdu 610072, Peoples R China[4]Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Dept Lab Med, Sichuan Prov Key Lab Human Dis Gene Study, Chengdu 610072, Peoples R China[6]Univ Elect Sci & Technol China, Sch Med, Chengdu 610047, Peoples R China[8]Yu Yue Pathol Sci Res Ctr, Chongqing 400039, Peoples R China[9]Jinfeng Lab, Chongqing 401329, Peoples R China
推荐引用方式(GB/T 7714)：
Yang Haochi,Wu Binghuo,Yang Qi,et al.Urolithin C suppresses colorectal cancer progression via the AKT/mTOR pathway[J].JOURNAL OF NATURAL MEDICINES.2024,78(4):887-900.doi:10.1007/s11418-024-01821-2.
APA：
Yang, Haochi,Wu, Binghuo,Yang, Qi,Tan, Tian,Shang, Dan...&Xu, Chuan.(2024).Urolithin C suppresses colorectal cancer progression via the AKT/mTOR pathway.JOURNAL OF NATURAL MEDICINES,78,(4)
MLA：
Yang, Haochi,et al."Urolithin C suppresses colorectal cancer progression via the AKT/mTOR pathway".JOURNAL OF NATURAL MEDICINES 78..4(2024):887-900
