机构：[1]Department of Immunology, West China School of Preclinical & Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, PR China[2]Department of Forensic Biology, West China School of Preclinical & Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, PR China[3]Department of Thyroid & Breast Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China[4]Department of Obstetrics & Gynaecology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China[5]Laboratory of Molecular & Translational Medicine, West China Institute of Women & Children’s Health, Key Laboratory of Birth Defects & Related Diseases of Women & Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China
IL-27 has potent antitumor effects. We aimed to examine the contribution of single nucleotide polymorphisms in IL-27 to the risk of papillary thyroid carcinoma (PTC).
IL-27 rs153109 and rs17855750 were analyzed in 496 PTC patients and 629 controls, using a polymerase chain reaction-restriction fragment length polymorphism method.
The rs153109 AG and AG/GG genotypes were significantly associated with increased risks for PTC. Significantly increased PTC risk was also associated with rs17855750 GT and GT/GG genotypes. Combined genotypes of rs153109 AG/GG and rs17855750 GT/GG increased the risk of PTC (p < 0.05).
These findings showed that IL-27 rs153109 and rs17855750 might be related to the tumorigenesis of PTC.
基金：
Special Research Foundation of Doctoral Priority to the Development of Field Project [20110181130013]; Science and Technology Pillar Program of Sichuan Province [2016SZ0013]
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|3 区医学
小类|4 区医学：研究与实验
最新[2023]版：
大类|4 区医学
小类|4 区医学：研究与实验
第一作者：
第一作者机构：[1]Department of Immunology, West China School of Preclinical & Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, PR China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Immunology, West China School of Preclinical & Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, PR China[5]Laboratory of Molecular & Translational Medicine, West China Institute of Women & Children’s Health, Key Laboratory of Birth Defects & Related Diseases of Women & Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China
推荐引用方式(GB/T 7714)：
Nie Xinwen,Yuan Fang,Chen Peng,et al.Association between IL-27 gene polymorphisms and risk of papillary thyroid carcinoma.[J].Biomarkers in medicine.2017,11(2):141-149.doi:10.2217/bmm-2016-0283.
APA：
Nie Xinwen,Yuan Fang,Chen Peng,Pu Yan,Zhu Jingqiang...&Zhang Lin.(2017).Association between IL-27 gene polymorphisms and risk of papillary thyroid carcinoma..Biomarkers in medicine,11,(2)
MLA：
Nie Xinwen,et al."Association between IL-27 gene polymorphisms and risk of papillary thyroid carcinoma.".Biomarkers in medicine 11..2(2017):141-149
