机构：[1]Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden[2]Exponent Inc, Health Sciences Practice, Menlo Park, California[3]Division of Epidemiology, Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California[4]Department of Cancer Prevention Center, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China其他部门肿瘤预防研究室中山大学肿瘤防治中心[5]State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China其他部门华南肿瘤学国家重点实验室中山大学肿瘤防治中心[6]Department of Clinical Laboratory, Wuzhou Red Cross Hospital, Wuzhou, Guangxi, China[7]Wuzhou Health System Key Laboratory for Nasopharyngeal Carcinoma Etiology and Molecular Mechanism, Wuzhou, Guangxi, China[8]Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China[9]Key Laboratory of High-Incidence Tumor Prevention and Treatment, Guangxi Medical University, Ministry of Education, Nanning, Guangxi, China[10]State Key Laboratory for Infectious Diseases Prevention and Control, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China[11]Sihui Cancer Institute Sihui, Guangdong, China[12]Cangwu Institute for Nasopharyngeal Carcinoma Control and Prevention, Wuzhou, Guangxi, China[13]Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts[14]Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts[15]Department of Microbiology, Tumor and Cell Biology Karolinska Institute, Stockholm, Sweden[16]Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington[17]Department of Epidemiology, University of Washington, Seattle, Washington[18]Beijing Hospital, Beijing, China
BACKGROUND: To the authors' knowledge, no studies to date have explored familial risks of nasopharyngeal carcinoma (NPC) in detail and quantified its lifetime risk in high-incidence populations. METHODS: The authors conducted a population-based case-control study of 2499 NPC cases and 2576 controls randomly selected in southern China from 2010 through 2014. Unconditional logistic regression was used to estimate multivariable-adjusted odds ratios (ORs) with 95% confidence intervals (95% CIs) associated with a family history of NPC. In addition, the authors compiled a reconstructed cohort comprising 40,781 first-degree relatives of cases and controls to calculate the lifetime cumulative risk of NPC. RESULTS: Individuals with a first-degree family history of NPC were found to be at a >4-fold risk of NPC (OR, 4.6; 95% CI, 3.5-6.1) compared with those without such a history, but had no excess risk of other malignancies. The excess risk was higher for a maternal than a paternal history and was slightly stronger for a sibling compared with a parental history, and for a sororal than a fraternal history. Among relatives of cases, the cumulative risk of NPC up to age 74 years was 3.7% (95% CI, 3.3%-4.2%), whereas that among relatives of controls was 0.9% (95% CI, 0.7%-1.2%). Cumulative risk was higher in siblings than in parents among relatives of cases, whereas no such difference was noted among relatives of controls. CONCLUSIONS: Individuals with a family history of NPC have a substantially higher risk of NPC. These relative and cumulative risk estimates can guide the development of strategies for early detection and clinical consultation in populations with a high incidence of NPC. (C) 2017 American Cancer Society.
基金：
National Cancer Institute of the National Institutes of Health [R01 CA115873]; Swedish Research Council [2015-02625, 2015-06268]; New Century Excellent Talents in University [NCET-12-0654]; National Basic Research Program of China [2011CB504300]; Guangxi Natural Science Foundation [2013GXNSFGA 019002]
语种：
外文
被引次数：
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PubmedID：
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出版当年[2017]版：
大类|2 区医学
小类|2 区肿瘤学
最新[2023]版：
大类|2 区医学
小类|2 区肿瘤学
第一作者：
第一作者机构：[1]Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
通讯作者：
通讯机构：[1]Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden[*1]Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77, Stockholm, Sweden
推荐引用方式(GB/T 7714)：
Liu Zhiwei,Chang Ellen T.,Liu Qing,et al.Quantification of Familial Risk of Nasopharyngeal Carcinoma in a High-Incidence Area[J].CANCER.2017,123(14):2716-2725.doi:10.1002/cncr.30643.
APA：
Liu, Zhiwei,Chang, Ellen T.,Liu, Qing,Cai, Yonglin,Zhang, Zhe...&Ye, Weimin.(2017).Quantification of Familial Risk of Nasopharyngeal Carcinoma in a High-Incidence Area.CANCER,123,(14)
MLA：
Liu, Zhiwei,et al."Quantification of Familial Risk of Nasopharyngeal Carcinoma in a High-Incidence Area".CANCER 123..14(2017):2716-2725
医学