机构：[1]Department of Urology, Institute of Urology, West China Hospital, SichuanUniversity, 37, Guo Xue Road, Chengdu 610041, China四川大学华西医院[2]State Key Laboratoryof Biotherapy and Cancer Center, Collaborative Innovation Center forBiotherapy, West China Hospital, Sichuan University, Chengdu, China四川大学华西医院[3]Department of Radiology, Chongqing Traditional Chinese Medicine Hospital,Chongqing, China[4]Department of Evidence-Based Medicine and Clinical Epidemiology, West China Hospital, Sichuan University, Chengdu, China四川大学华西医院
The relationship between first-degree family history of female breast cancer and prostate cancer risk in the general population remains unclear. We performed a meta-analysis to determine the association between first-degree family history of female breast cancer and prostate cancer risk.
Databases, including MEDLINE, Embase, and Web of Science, were searched for all associated studies that evaluated associations between first-degree family history of female breast cancer and prostate cancer risk up to December 31, 2018. Information on study characteristics and outcomes were extracted based on the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) statement and Meta-analysis of Observational Studies in Epidemiology (MOOSE) guidelines. The quality of evidence was assessed using the GRADE approach.
Eighteen studies involving 17,004,892 individuals were included in the meta-analysis. Compared with no family history of female breast cancer, history of female breast cancer in first-degree relatives was associated with an increased risk of prostate cancer [relative risk (RR) 1.18, 95% confidence interval (CI) 1.12-1.25] with moderate-quality evidence. A history of breast cancer in mothers only (RR 1.19, 95% CI 1.10-1.28) and sisters only (RR 1.71, 95% CI 1.43-2.04) was associated with increased prostate cancer risk with moderate-quality evidence. However, a family history of breast cancer in daughters only was not associated with prostate cancer incidence (RR 1.74, 95% CI 0.74-4.12) with moderate-quality evidence. A family history of female breast cancer in first-degree relatives was associated with an 18% increased risk of lethal prostate cancer (95% CI 1.04-1.34) with low-quality evidence.
This review demonstrates that men with a family history of female breast cancer in first-degree relatives had an increased risk of prostate cancer, including risk of lethal prostate cancer. These findings may guide screening, earlier detection, and treatment of men with a family history of female breast cancer in first-degree relatives.
基金：
This work was supported by a Key Project of National Natural Science
Foundation of China; Grant ID: 8177060452; This work was supported by Key
Research and Development Project of Science and Technology Department
of Sichuan Province, Grant ID: 2017SZ0067; and 1.3.5 project for disciplines of
excellence, West China Hospital, Sichuan University, Grant ID: ZY2016104
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|3 区医学
小类|3 区肿瘤学
最新[2023]版：
大类|2 区医学
小类|3 区肿瘤学
第一作者：
第一作者机构：[1]Department of Urology, Institute of Urology, West China Hospital, SichuanUniversity, 37, Guo Xue Road, Chengdu 610041, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Ren Zheng-Ju,Cao De-Hong,Zhang Qin,et al.First-degree family history of breast cancer is associated with prostate cancer risk: a systematic review and meta-analysis.[J].BMC cancer.2019,19(1):871.doi:10.1186/s12885-019-6055-9.
APA：
Ren Zheng-Ju,Cao De-Hong,Zhang Qin,Ren Peng-Wei,Liu Liang-Ren...&Dong Qiang.(2019).First-degree family history of breast cancer is associated with prostate cancer risk: a systematic review and meta-analysis..BMC cancer,19,(1)
MLA：
Ren Zheng-Ju,et al."First-degree family history of breast cancer is associated with prostate cancer risk: a systematic review and meta-analysis.".BMC cancer 19..1(2019):871
医学