机构:[1]Dalian Med Univ, Affiliated Hosp 1, Dept Gen Surg, Dalian, Peoples R China大连医科大学附属第一医院[2]Dalian Med Univ, Affiliated Hosp 1, Clin Lab Integrat Med, Dalian, Peoples R China大连医科大学附属第一医院[3]Univ Sci & Technol China, Univ Sci & Technol China USTC, Affiliated Hosp 1, Div Life Sci & Med,Dept Gen Surg, Hefei, Peoples R China[4]North Sichuan Med Coll, Affiliated Hosp, Dept Hepatobiliary Pancreas, Nanchong, Peoples R China[5]iPhenome Biotechnol Yun Pu Kang Inc, Dalian, Peoples R China[6]Dalian Med Univ, Inst Integrat Med, Dalian, Peoples R China
Gastric cancer (GC) is a common lethal malignancy worldwide. Gastroscopy is an effective screening technique for decreasing mortality. However, there are still limited useful non-invasive markers for early detection of GC. Bile acids are important molecules for the modulation of energy metabolism. With an in-depth targeted method for accurate quantitation of 80 bile acids (BAs), we aimed to find potential biomarkers for the early screening of GC. A cohort with 280 participants was enrolled, including 113 GC, 22 benign gastric lesions (BGL) and 145 healthy controls. Potential markers were identified using a random forest machine algorithm in the discovery cohort (n=180), then validated in an internal validation cohort (n=78) and a group with 22 BGL. The results represented significant alterations in the circulating BA pool between GC and the controls. BAs also exhibited significant correlations with various clinical traits. Then, we developed a diagnostic panel that comprised six BAs or ratios for GC detection. The panel showed high accuracy for the diagnosis of GC with AUC of 1 (95%CI: 1.00-1.00) and 0.98 (95%CI: 0.93-1.00) in the discovery and validation cohort, respectively. This 6-BAs panel was also able to identify early GC with AUC of 1 (95%CI: 0.999-1.00) and 0.94 (95%CI: 0.83-1.00) in the discovery and validation cohort, respectively. Meanwhile, this panel achieved a good differential diagnosis between GC and BGL and the AUC was 0.873 (95%CI: 0.812-0.934). The alternations of serum bile acids are characteristic metabolic features of GC. Bile acids could be promising biomarkers for the early diagnosis of GC.
基金:
Key Research And Development Project Of Liaoning Province; National Natural Science Foundation of China; [2018225054]; [81873156]
第一作者机构:[1]Dalian Med Univ, Affiliated Hosp 1, Dept Gen Surg, Dalian, Peoples R China[2]Dalian Med Univ, Affiliated Hosp 1, Clin Lab Integrat Med, Dalian, Peoples R China[3]Univ Sci & Technol China, Univ Sci & Technol China USTC, Affiliated Hosp 1, Div Life Sci & Med,Dept Gen Surg, Hefei, Peoples R China
共同第一作者:
通讯作者:
通讯机构:[2]Dalian Med Univ, Affiliated Hosp 1, Clin Lab Integrat Med, Dalian, Peoples R China[6]Dalian Med Univ, Inst Integrat Med, Dalian, Peoples R China
推荐引用方式(GB/T 7714):
Pan Chen,Deng Dawei,Wei Tianfu,et al.Metabolomics study identified bile acids as potential biomarkers for gastric cancer: A case control study[J].FRONTIERS IN ENDOCRINOLOGY.2022,13:doi:10.3389/fendo.2022.1039786.
APA:
Pan, Chen,Deng, Dawei,Wei, Tianfu,Wu, Zeming,Zhang, Biao...&Yin, Peiyuan.(2022).Metabolomics study identified bile acids as potential biomarkers for gastric cancer: A case control study.FRONTIERS IN ENDOCRINOLOGY,13,
MLA:
Pan, Chen,et al."Metabolomics study identified bile acids as potential biomarkers for gastric cancer: A case control study".FRONTIERS IN ENDOCRINOLOGY 13.(2022)