机构：[1]Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden[2]Exponent, Inc., Health Sciences Practice, Menlo Park, CA, USA[3]Division of Epidemiology, Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA, USA[4]Department of Cancer Prevention Center, Sun Yat-sen University Cancer Center, Guangzhou, China其他部门肿瘤预防研究室中山大学肿瘤防治中心[5]State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China其他部门华南肿瘤学国家重点实验室中山大学肿瘤防治中心[6]Department of Clinical Laboratory, Wuzhou Red Cross Hospital, Wuzhou, China[7]Wuzhou Health System Key Laboratory for Nasopharyngeal Carcinoma Etiology and Molecular Mechanism, Wuzhou, China[8]Department of Otolaryngology-Head & Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, China[9]Key Laboratory of High-Incidence-Tumor Prevention & Treatment (Guangxi Medical University), Ministry of Education, Nanning, China[10]State Key Laboratory for Infectious Diseases Prevention and Control, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China[11]Sihui Cancer Institute, Sihui, China[12]Cangwu Institute for Nasopharyngeal Carcinoma Control and Prevention, Wuzhou, China[13]Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA[14]Department of Biostatistics, Harvard TH Chan School of Public Health, Boston, MA, USA[15]Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden[16]Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA[17]Department of Epidemiology, University of Washington, Seattle, WA, USA[18]Beijing Hospital, Beijing, China
With its population of over 1.3 billion persons, China offers abundant opportunities to discover causes of disease. However, few rigorous population-based case-control studies have as yet been conducted in mainland China. We conducted a population-based case-control study of nasopharyngeal carcinoma in Guangdong Province and Guangxi Autonomous Region. We collected questionnaires and biospecimens from incident cases recruited between March 2010 and December 2013, and population-based controls between November 2010 and November 2014. Preparatory activities prior to subject enrollment required approximately 18 months. We enrolled a total of 2554 NPC cases and 2648 controls. Among all identified cases, 83.8% participated. For the participating cases, the median time between diagnosis and interview was 2 days. Among all contacted controls, 82.7% participated. From the enrolled cases, we collected 2518 blood specimens (provided by 98.6% of eligible cases), 2350 saliva specimens (92.0%), 2514 hair specimens (98.4%), and 2507 toenail/fingernail specimens (98.2%). From the enrolled controls, we collected 2416 blood specimens (91.2%), 2505 saliva specimens (94.6%), 2517 hair specimens (95.1%), and 2514 toenail/ fingernail specimens (94.9%). We demonstrate that population-based epidemiologic research can successfully be conducted in southern China. The study protocols, databases, and biobank will serve as an extraordinarily valuable resource for testing future etiologic hypotheses.
基金：
National Cancer Institute at the U.S, National Institutes of Health [R01 CA115873]; Swedish Research Council [2015-02625, 2015-06268]; New Century Excellent Talents in University [NCET-12-0654]; National Basic Research Program of China [2011CB504300]; Guangxi Natural Science Foundation [2013GXNSFGA 019002]; Karolinska Institutet [2368/10-221]; Karolinska Institutet (KID)
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|2 区医学
小类|2 区肿瘤学3 区细胞生物学
最新[2023]版：
无
第一作者：
第一作者机构：[1]Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
通讯作者：
通讯机构：[1]Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
推荐引用方式(GB/T 7714)：
Ye Weimin,Chang Ellen T.,Liu Zhiwei,et al.Development of a population-based cancer case-control study in southern china[J].ONCOTARGET.2017,8(50):87073-87085.doi:10.18632/oncotarget.19692.
APA：
Ye, Weimin,Chang, Ellen T.,Liu, Zhiwei,Liu, Qing,Cai, Yonglin...&Adami, Hans-Olov.(2017).Development of a population-based cancer case-control study in southern china.ONCOTARGET,8,(50)
MLA：
Ye, Weimin,et al."Development of a population-based cancer case-control study in southern china".ONCOTARGET 8..50(2017):87073-87085
