BackgroundThis study provides a comprehensive analysis of the global, regional, and national epidemiology of acute myeloid leukemia (AML) from 1990 to 2021, focusing on incidence, mortality, and disability-adjusted life years (DALYs).MethodsUsing data from the Global Burden of Disease (GBD) study, we investigated the trends and patterns of AML across 204 countries and territories during 1990 to 2021. All statistical analyses and data visualizations were performed using R (version 4.4.2) and JD_GBDR (V2.36).ResultsThe global incidence of AML increased by 82.25% from 79.37 x 10(3) cases in 1990 to 144.65 x 10(3) cases in 2021, with significant variations across regions. AML-related deaths increased by 73.77% globally, from 74.92 x 10(3) in 1990 to 130.19 x 10(3) in 2021. DALYs rose by 23.70%, from 3342.91 x 10(3) in 1990 to 4135.06 x 10(3) in 2021.ConclusionsHigh SDI regions face higher incidence and mortality due to advanced diagnostics and aging, while low-middle SDI regions show rapid increases likely due to urbanization and lifestyle changes. Addressing these disparities requires improved healthcare infrastructure, early detection, and targeted interventions, particularly in low- and middle-income countries (LMICs).
基金：
National Natural Science Foundation of China [82300137, 82403559, 82100174]; Sichuan Science and Technology Program [2024NSFSC1698]; Natural Science Foundation of Chongqing [CSTB2023NSCQ-MSX0065]; China Postdoctoral Science Foundation [2024M750362]; Young Talents Fund of Sichuan Provincial People's Hospital [2022QN01]
第一作者机构：[1]CAMS & PUMC, Inst Blood Transfus, Chengdu, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[2]Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Dept Urol, Chengdu, Peoples R China[3]Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Canc Inst, Chengdu, Peoples R China[9]Jinfeng Lab, Chongqing, Peoples R China[*1]department of Urology, sichuan Provincial People’s Hospital, Universityof electronic science and Technology of china, chengdu, china[*2]cancer institute, sichuanProvincial People’s Hospital, University of electronic science and Technology of china, chengdu, china
推荐引用方式(GB/T 7714)：
Wu Binghuo,Song Fei,Han Xue,et al.Global, regional and national epidemiology of acute myeloid leukemia (1990-2021): a statistical analysis of incidence, mortality, and DALYs[J].ANNALS OF MEDICINE.2025,57(1):doi:10.1080/07853890.2025.2557507.
APA：
Wu, Binghuo,Song, Fei,Han, Xue,Zhao, Minyi,Huang, Meijia...&Cheng, Songtao.(2025).Global, regional and national epidemiology of acute myeloid leukemia (1990-2021): a statistical analysis of incidence, mortality, and DALYs.ANNALS OF MEDICINE,57,(1)
MLA：
Wu, Binghuo,et al."Global, regional and national epidemiology of acute myeloid leukemia (1990-2021): a statistical analysis of incidence, mortality, and DALYs".ANNALS OF MEDICINE 57..1(2025)
