详情页 - 四川省肿瘤医院知识库

当前位置：首页 > 详情页

Integration of PET/CT parameters and a clinical variable to predict the risk of progression of disease within 24 months (POD24) in follicular lymphoma

文献详情

资源类型：

Pubmed体系：

作者：

机构： [1]Department of Hematology, the First Affiliated Hospital of Xiamen University and Institute of Hematology, School of Medicine, Xiamen University, Xiamen, China. [2]Key Laboratory of Xiamen for Diagnosis and Treatment of Hematological Malignancy, Xiamen, China. [3]Department of Nuclear Medicine, the West China Hospital of Sichuan University, Chengdu, China. [4]Department of Nuclear Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

出处：

DOI：

ISSN：

关键词： Follicular lymphoma (FL) positron emission tomography/computed tomography (PET/CT) progression of disease within 24 months (POD24)

摘要：

Patients with follicular lymphoma (FL) who experience progression of disease within 24 months (POD24) of receiving first-line therapy had a significantly poorer prognosis than that without early progression. Due to the established prognostic relevance of positron emission tomography/computed tomography (PET/CT) parameters in FL and their clinical accessibility, we aimed to investigate the predictive role of PET/CT metabolism and dissemination parameters in POD24 for FL.The POD24 status of 155 patients who underwent PET/CT examinations at initial diagnosis was evaluated. Various baseline characteristics were collected, along with PET/CT-derived parameters, including the maximum tumor dissemination (Dmax), maximum standardized uptake (SUVmax) value, total metabolic tumor volume (TMTV), and total lesion glycolysis (TLG). A Cox proportional regression analysis was used to identify potential risk predictors of POD24. Receiver operating characteristic (ROC) curves were used to define the optimal cut-off values.In our cohort, POD24 was observed in 21 (13.5%) FL patients. The univariate and multivariate Cox regression analyses revealed that elevated lactate dehydrogenase (LDH) was a significant predictor of POD24. Additionally, survival analyses based on the cut-off values showed that the risk of POD24 was significantly increased in patients with a Dmax >64.24 cm, SUVmax >11.23, TMTV >144.16 cm2, and TLG >586.79 g. Further, a Dmax >64.24 cm, a TMTV >144.16 cm2, and elevated LDH were selected for inclusion in a risk model [concordance index (C-index) =0.82], and the patients were divided into three risk groups, in which the rates of POD24 were 1.69%, 10.42%, and 35.29%, respectively (P<0.001). Our model exhibited excellent performance in terms of both the C-index and ROC curve analysis, surpassing the performance of models commonly used in the field.PET/CT parameters have prognostic value for POD24 in FL. The risk model, which combined PET/CT parameters with clinical indicators, could improve risk stratification and help guide therapeutic decisions.Copyright © 2025 AME Publishing Company. All rights reserved.

基金：

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2025]版：

大类 | 3 区医学

小类 | 3 区核医学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区核医学

第一作者：

第一作者机构： [1]Department of Hematology, the First Affiliated Hospital of Xiamen University and Institute of Hematology, School of Medicine, Xiamen University, Xiamen, China. [2]Key Laboratory of Xiamen for Diagnosis and Treatment of Hematological Malignancy, Xiamen, China.

共同第一作者：

通讯作者：

通讯机构： [1]Department of Hematology, the First Affiliated Hospital of Xiamen University and Institute of Hematology, School of Medicine, Xiamen University, Xiamen, China. [2]Key Laboratory of Xiamen for Diagnosis and Treatment of Hematological Malignancy, Xiamen, China.

推荐引用方式(GB/T 7714)：

APA：

MLA：

Integration of PET/CT parameters and a clinical variable to predict the risk of progression of disease within 24 months (POD24) in follicular lymphoma

文献详情

相关文献