Selenium-Albumin Nanoaccelerator Hydrogel Promotes Wound Healing by Antibacterial, Anti-Inflammatory and Antioxidant along with Inhibits Scar Formation via Downregulating CD36
Wounds repairing after skin damage or diabetes remain a vast medical challenge, which often faces infection, inflammation, oxidative stress, and skin scarring. Herein, a multifunctional selenium-albumin nanoaccelerator hydrogel (H-Se NPs-Gel) is constructed based on the self-assembly of human serum albumin (HSA) with selenium nanoparticles (Se NPs) using carbomer as the carrier, it has remarkable antibacterial, anti-inflammatory, antioxidant and inhibits scarring properties than Se NPs for wound healing. Compared with Se NPs, H-Se NPs exhibit smaller particle sizes, exceptional stability, better antibacterial activity against common bacteria and MRSA, and superior antioxidant and anti-inflammatory capabilities in vitro without remarkable toxicity on skin cells. Importantly, it exhibits superior efficacy to Se NPs-Gel in accelerating the healing of full-thickness skin defects and diabetic wounds in mice. Interestingly, in a hypertrophic scar (HTS) model, H-Se NPs-Gel is more effective than Se NPs-Gel in inhibiting collagen formation to suppress scarring, which is mediated by the inhibition of CD36. The antagonistic effect of H-Se NPs on CD36 is also proved with the CD36 overexpression model. Furthermore, H-Se NPs-Gel demonstrates excellent safety in mice without systemic toxicity. H-Se NPs-Gel is an effective and safe therapy strategy for promoting wound healing and reducing scar formation in clinic.
基金:
Key Research and Development Project of Hunan Province; Chongqing Natural Science Foundation [CSTB2022NSCQ-MSX0857]; China Postdoctoral Science Foundation [2023M740446]; Future Medical Youth Innovation Team of Chongqing Medical University [2022-W0032-PI/Jin Chen]; Chongqing Graduate Research Innovation Project [CYB23219]; [2023NK2022]; [2023SK2008]
第一作者机构:[1]Chongqing Med Univ, Coll Pharm, Key Lab Biochem & Mol Pharmacol, Chongqing Key Lab Pharmaceut Metab Res, Chongqing 400010, Peoples R China
通讯作者:
通讯机构:[1]Chongqing Med Univ, Coll Pharm, Key Lab Biochem & Mol Pharmacol, Chongqing Key Lab Pharmaceut Metab Res, Chongqing 400010, Peoples R China[2]Chongqing Med Univ, Hosp Mianyang 3, Affiliated Mianyang Hosp, Sichuan Mental Hlth Ctr, Mianyang 621000, Peoples R China[3]Chongqing Med Univ, Affiliated Hosp 1, Dept Dermatol, Chongqing 400010, Peoples R China
推荐引用方式(GB/T 7714):
Zhao Lulu,Wang Junyi,Pan Yu,et al.Selenium-Albumin Nanoaccelerator Hydrogel Promotes Wound Healing by Antibacterial, Anti-Inflammatory and Antioxidant along with Inhibits Scar Formation via Downregulating CD36[J].ADVANCED HEALTHCARE MATERIALS.2025,doi:10.1002/adhm.202500699.
APA:
Zhao, Lulu,Wang, Junyi,Pan, Yu,Tan, Fengjian,Wang, Tianlun...&Peng, Yongbo.(2025).Selenium-Albumin Nanoaccelerator Hydrogel Promotes Wound Healing by Antibacterial, Anti-Inflammatory and Antioxidant along with Inhibits Scar Formation via Downregulating CD36.ADVANCED HEALTHCARE MATERIALS,,
MLA:
Zhao, Lulu,et al."Selenium-Albumin Nanoaccelerator Hydrogel Promotes Wound Healing by Antibacterial, Anti-Inflammatory and Antioxidant along with Inhibits Scar Formation via Downregulating CD36".ADVANCED HEALTHCARE MATERIALS .(2025)