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Selenium-Albumin Nanoaccelerator Hydrogel Promotes Wound Healing by Antibacterial, Anti-Inflammatory and Antioxidant along with Inhibits Scar Formation via Downregulating CD36

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机构: [1]Chongqing Med Univ, Coll Pharm, Key Lab Biochem & Mol Pharmacol, Chongqing Key Lab Pharmaceut Metab Res, Chongqing 400010, Peoples R China [2]Chongqing Med Univ, Hosp Mianyang 3, Affiliated Mianyang Hosp, Sichuan Mental Hlth Ctr, Mianyang 621000, Peoples R China [3]Chongqing Med Univ, Affiliated Hosp 1, Dept Dermatol, Chongqing 400010, Peoples R China [4]Cent South Univ, Canc Res Inst, Changsha 410083, Peoples R China [5]Cent South Univ, Sch Basic Med Sci, Changsha 410083, Peoples R China [6]Hunan Univ, Coll Biol, Changsha 410082, Peoples R China
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关键词: Antibacterial Anti-inflammatory Antioxidant Selenium-albumin nanoaccelerator Wound healing

摘要:
Wounds repairing after skin damage or diabetes remain a vast medical challenge, which often faces infection, inflammation, oxidative stress, and skin scarring. Herein, a multifunctional selenium-albumin nanoaccelerator hydrogel (H-Se NPs-Gel) is constructed based on the self-assembly of human serum albumin (HSA) with selenium nanoparticles (Se NPs) using carbomer as the carrier, it has remarkable antibacterial, anti-inflammatory, antioxidant and inhibits scarring properties than Se NPs for wound healing. Compared with Se NPs, H-Se NPs exhibit smaller particle sizes, exceptional stability, better antibacterial activity against common bacteria and MRSA, and superior antioxidant and anti-inflammatory capabilities in vitro without remarkable toxicity on skin cells. Importantly, it exhibits superior efficacy to Se NPs-Gel in accelerating the healing of full-thickness skin defects and diabetic wounds in mice. Interestingly, in a hypertrophic scar (HTS) model, H-Se NPs-Gel is more effective than Se NPs-Gel in inhibiting collagen formation to suppress scarring, which is mediated by the inhibition of CD36. The antagonistic effect of H-Se NPs on CD36 is also proved with the CD36 overexpression model. Furthermore, H-Se NPs-Gel demonstrates excellent safety in mice without systemic toxicity. H-Se NPs-Gel is an effective and safe therapy strategy for promoting wound healing and reducing scar formation in clinic.

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出版当年[2025]版:
大类 | 2 区 医学
小类 | 2 区 工程:生物医学 2 区 材料科学:生物材料 2 区 纳米科技
最新[2025]版:
大类 | 2 区 医学
小类 | 2 区 工程:生物医学 2 区 材料科学:生物材料 2 区 纳米科技
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最新[2023]版:
Q1 ENGINEERING, BIOMEDICAL Q1 MATERIALS SCIENCE, BIOMATERIALS Q1 NANOSCIENCE & NANOTECHNOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2024版] 出版当年五年平均 出版前一年[2024版]

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第一作者机构: [1]Chongqing Med Univ, Coll Pharm, Key Lab Biochem & Mol Pharmacol, Chongqing Key Lab Pharmaceut Metab Res, Chongqing 400010, Peoples R China
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通讯机构: [1]Chongqing Med Univ, Coll Pharm, Key Lab Biochem & Mol Pharmacol, Chongqing Key Lab Pharmaceut Metab Res, Chongqing 400010, Peoples R China [2]Chongqing Med Univ, Hosp Mianyang 3, Affiliated Mianyang Hosp, Sichuan Mental Hlth Ctr, Mianyang 621000, Peoples R China [3]Chongqing Med Univ, Affiliated Hosp 1, Dept Dermatol, Chongqing 400010, Peoples R China
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