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Carbohydrate polymer-based nanoparticles in curcumin delivery for cancer therapy: A review

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机构： [1]Otolaryngology & Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang 310014, China [2]Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Hangzhou, Zhejiang 310014, China [3]Zhejiang Provincial Clinical Research Center for Malignant Tumor, Hangzhou, Zhejiang 310014, China [4]Department of Pathology, Air Force Medical Center, PLA, Beijing, China [5]Nursing Department, Shandong First Medical University Affiliated Occupational Disease Hospital (Shandong Provincial Occupational Disease Hospital), Jinan, China [6]Department of Breast Surgery, Sichuan Clinical Research Center for Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu 610041, Sichuan, China [7]Department of Traditional Chinese Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China [8]Department of Urology, Kidney and Urology Center, Pelvic Floor Disorders Center, Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen 518107, Guangdong, China

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关键词： Curcumin Nanoparticles Cancer

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The use of natural products for cancer treatment has a lengthy history. The safety and multifunctionality of naturally occurring substances have rendered them appropriate for cancer treatment. Curcumin influences multiple molecular pathways and is advantageous for treating both hematological and solid tumors. Nonetheless, the effectiveness of curcumin in vivo and in clinical studies has faced scrutiny due to its inadequate pharmacokinetic profile. Consequently, nanoparticles have been created for the administration of curcumin in cancer treatment. The nanoparticles can enhance the distribution of curcumin in tissues and increase its therapeutic effectiveness. Furthermore, nanoparticles expand the uptake of curcumin in cancer cells, leading to heightened cytotoxicity. Carbohydrate nanoparticles provide a promising solution for delivering curcumin in cancer treatment by tackling its low solubility, limited bioavailability, and quick degradation. These biodegradable and biocompatible carriers, originating from polymers such as chitosan, hyaluronic acid, and alginate, safeguard curcumin, improving its stability and allowing for controlled release. Targeting ligands for functionalization guarantee selective distribution to tumor cells, enhancing therapeutic effectiveness and reducing off-target impacts. Their capacity to encapsulate curcumin with other agents allows for synergistic therapies, enhancing anticancer results even more. The adjustable characteristics of carbohydrate nanoparticles, along with their minimal toxicity, create a revolutionary platform.Copyright © 2025. Published by Elsevier B.V.

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大类 | 1 区

化学

小类 | 1 区应用化学 1 区高分子科学 2 区生化与分子生物学

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第一作者机构： [1]Otolaryngology & Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang 310014, China [2]Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Hangzhou, Zhejiang 310014, China [3]Zhejiang Provincial Clinical Research Center for Malignant Tumor, Hangzhou, Zhejiang 310014, China

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