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Review of Curcumin Physicochemical Targeting Delivery System.

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机构: [1]Central Nervous System Drug KeyLaboratory of Sichuan Province, Schoolof Pharmacy, Southwest MedicalUniversity, Luzhou, Sichuan 646000,People’s Republic of China [2]NanchongKey Laboratory of Individualized DrugTherapy, Department of Pharmacy, TheSecond Clinical Medical College of NorthSichuan Medical College, NanchongCentral Hospital, Nanchong, Sichuan637000, People’s Republic of China [3]Institute of Medicinal Chemistry ofChinese Medicine, Chongqing Academyof Chinese MateriaMedica, Chongqing400065, People’s Republic of China [4]Department of Oncology of LuzhouPeople’s Hospital, Luzhou, Sichuan646000, People’s Republic of China [5]Basic Medical College of SouthwestMedical University, Luzhou, Sichuan646000, People’s Republic of China
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摘要:
Curcumin (CUR), as a traditional Chinese medicine monomer extracted from the rhizomes of some plants in Ginkgo and Araceae, has shown a wide range of therapeutic and pharmacological activities such as anti-tumor, anti-inflammatory, anti-oxidation, anti-virus, anti-liver fibrosis, anti-atherosclerosis, and anti-Alzheimer's disease. However, some issues significantly affect its biological activity, such as low aqueous solubility, physico-chemical instability, poor bioavailability, and low targeting efficacy. In order to further improve its curative effect, numerous efficient drug delivery systems have been carried out. Among them, physicochemical targeting preparations could improve the properties, targeting ability, and biological activity of CUR. Therefore, in this review, CUR carrier systems are discussed that are driven by physicochemical characteristics of the microenvironment (eg, pH variation of tumorous tissues), affected by external influences like magnetic fields and vehicles formulated with thermo-sensitive materials. © 2020 Li et al.

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出版当年[2020]版:
大类 | 2 区 医学
小类 | 2 区 药学 3 区 纳米科技
最新[2023]版:
大类 | 2 区 医学
小类 | 2 区 药学 3 区 纳米科技
第一作者:
第一作者机构: [1]Central Nervous System Drug KeyLaboratory of Sichuan Province, Schoolof Pharmacy, Southwest MedicalUniversity, Luzhou, Sichuan 646000,People’s Republic of China [2]NanchongKey Laboratory of Individualized DrugTherapy, Department of Pharmacy, TheSecond Clinical Medical College of NorthSichuan Medical College, NanchongCentral Hospital, Nanchong, Sichuan637000, People’s Republic of China
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通讯机构: [1]Central Nervous System Drug KeyLaboratory of Sichuan Province, Schoolof Pharmacy, Southwest MedicalUniversity, Luzhou, Sichuan 646000,People’s Republic of China [*1]School of Pharmacy, Southwest Medical University, No. 3-319, Zhongshan Road, Jiangyang District, Luzhou City, Sichuan Province 646000, People’s Republic of China
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