机构：[1]Department of Thoracic and Cardiovascular Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China[2]Department of Thoracic Surgery, Sichuan Cancer Hospital, Chengdu, China外科中心胸外科中心四川省肿瘤医院胸外科
This study mainly investigated the effects of matrine on cell apoptosis and the effects of anticancer drugs in non-small cell lung cancer (NSCLC) cell lines (A549 and LK2 cells). The results showed that matrine (10 M) caused a significant inhibition on cell viability and 10 and 100 M matrine induced cell apoptosis via influencing p53, bax, casp3, and bcl-2 expressions in A549 cells. In addition, matrine significantly down-regulated C-C chemokine receptor type 7 (CCR7) expression, and blocking the down-regulation of CCR7 by exogenous chemokine ligand 21 (CCL21) treatment alleviated matrine-caused effects of apoptosis genes in A549 cells. The results were further validated in LK2 cells that matrine regulated apoptosis gene expressions, which were reversed by CCL21 treatment. Furthermore, matrine enhances the effects of cisplatin, 5-fluorouracil, and paclitaxel in A549 cells, and the anticancer effects exhibit a dosage-dependent manner. In summary, matrine induced cell apoptosis and enhanced the effects of anticancer drugs in NSCLC cells; the mechanism might be associated with the CCR7 signal.
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|3 区生物
小类|4 区生化与分子生物学4 区免疫学4 区医学：研究与实验4 区微生物学
最新[2023]版：
大类|4 区医学
小类|4 区生化与分子生物学4 区免疫学4 区医学：研究与实验4 区微生物学
JCR分区：
出版当年[2018]版：
Q3MICROBIOLOGYQ3BIOCHEMISTRY & MOLECULAR BIOLOGYQ3MEDICINE, RESEARCH & EXPERIMENTALQ4IMMUNOLOGY
最新[2023]版：
Q2MEDICINE, RESEARCH & EXPERIMENTALQ3BIOCHEMISTRY & MOLECULAR BIOLOGYQ3IMMUNOLOGYQ3MICROBIOLOGY
第一作者机构：[1]Department of Thoracic and Cardiovascular Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China[*1]Department of Thoracic and Cardiovascular Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China
通讯作者：
通讯机构：[1]Department of Thoracic and Cardiovascular Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China[*1]Department of Thoracic and Cardiovascular Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China
推荐引用方式(GB/T 7714)：
Pu Jiangtao,Tang Xiaojun,Zhuang Xiang,et al.Matrine induces apoptosis via targeting CCR7 and enhances the effect of anticancer drugs in non-small cell lung cancer in vitro[J].INNATE IMMUNITY.2018,24(7):394-399.doi:10.1177/1753425918800555.
APA：
Pu, Jiangtao,Tang, Xiaojun,Zhuang, Xiang,Hu, Zhi,He, Kaiming...&Dai, Tianyang.(2018).Matrine induces apoptosis via targeting CCR7 and enhances the effect of anticancer drugs in non-small cell lung cancer in vitro.INNATE IMMUNITY,24,(7)
MLA：
Pu, Jiangtao,et al."Matrine induces apoptosis via targeting CCR7 and enhances the effect of anticancer drugs in non-small cell lung cancer in vitro".INNATE IMMUNITY 24..7(2018):394-399
