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Artemisinin Suppressed Melanoma Recurrence and Metastasis after Radical Surgery through the KIT/PI3K/AKT Pathway

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机构： [1]Cancer Center and Center of Reproduction, Development & Aging, Institute of Translation Medicine, Faculty of Health Sciences, University of Macau, Taipa, Macau, China. [2]MOE Frontier Science Center for Precision Oncology, University of Macau, Macau, China. [3]Department of Neurosurgery, Affiliated Hospital of Southwest Medical University, 25 Taiping Street, Luzhou, Sichuan, China. [4]Southern Medical University Cancer Institute, Southern Medical University, 1023 Shatai South Road, Guangzhou, Guangdong, China. [5]Guangdong-Hong Kong-Macao Joint Laboratory for New Drug Screening, University of Macau, Macau, China.

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关键词： artemisinin melanoma post-surgery model c-KIT AKT

摘要：

Cancer radical surgery is the primary treatment for melanoma, but almost all malignant melanoma patients get recurrence and metastasis after surgery and are eventually dead. This clinical dilemma appeals to better drugs for post-surgery therapy. Artemisinin is a safe and effective antimalarial drug used in the clinic for decades. However, no information is available regarding the effect of Artemisinins on melanoma recurrence and metastasis after tumor excision. In the present study, we established a post-surgery tumor model on balb/c nude mice, and we found that subclinical dosages of Artemisinin significantly blocked recurrence, metastasis, and extended survival time of mice after tumor excision. Similar results were obtained in the in vitro experiments with B16 and A375 cell lines. Further experiments confirmed that Artemisinin inhibits melanoma in vitro and in vivo after radical surgery by the c-KIT/PI3K/AKT signaling pathway. Our findings support the therapeutic potential of Artemisinin in malignant melanoma after surgery.© The author(s).

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最新[2023]版：

大类 | 2 区

生物学

小类 | 2 区生化与分子生物学

第一作者：

第一作者机构： [1]Cancer Center and Center of Reproduction, Development & Aging, Institute of Translation Medicine, Faculty of Health Sciences, University of Macau, Taipa, Macau, China. [2]MOE Frontier Science Center for Precision Oncology, University of Macau, Macau, China.

通讯作者：

通讯机构： [1]Cancer Center and Center of Reproduction, Development & Aging, Institute of Translation Medicine, Faculty of Health Sciences, University of Macau, Taipa, Macau, China. [2]MOE Frontier Science Center for Precision Oncology, University of Macau, Macau, China. [5]Guangdong-Hong Kong-Macao Joint Laboratory for New Drug Screening, University of Macau, Macau, China.

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