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Lasalocid inhibits melanoma by down-regulating FOXM1 through PI3K/AKT and JNK/P38 MAPK pathways

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机构： [1]Department of Pharmacy, The Second Clinical Medical College of North Sichuan Medical College, Nanchong, Sichuan, China, 637003. [2]School of Pharmacy, North Sichuan Medical College, Nanchong, China, 637100. [3]Department of Pharmacy, The Affiliated Hospital of North Sichuan Medical College, Nanchong, China, 637002. [4]Nanchong Key Laboratory of Individualized Drug Therapy, Nanchong, China, 637003. [5]Department of Oncology, The Second Clinical Medical College of North Sichuan Medical College, Nanchong, China, 637003. [6]Institute of Tissue Engineering and Stem Cells, The Second Clinical Medical College of North Sichuan Medical College, Nanchong, China, 637003.

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关键词： Lasalocid FOXM1 PI3K/AKT signaling pathway JNK/P38 MAPK signaling pathway Melanoma

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Melanoma poses a significant challenge to patients due to its aggressive nature and limited treatment options. Recent studies have suggested that lasalocid, a feed additive ionophore antibiotic, may have potential as an anticancer agent. However, the mechanism of lasalocid in melanoma is unclear. This study found that lasalocid could inhibit melanoma cell proliferation, migration, and invasion, while inducing cell cycle arrest and apoptosis. Transcriptome sequencing and bioinformatics analysis identified FOXM1 as the hub gene of lasalocid-mediated melanoma treatment. In vitro experiments confirmed that lasalocid regulates FOXM1 expression through the PI3K/AKT and JNK/P38 MAPK pathways. In vivo experiments showed that lasalocid effectively inhibited melanoma growth with acceptable safety. In summary, our study results emphasize lasalocid's potential as a melanoma therapeutic agent and elucidate its role in regulating FOXM1 through the PI3K/AKT and JNK/P38 MAPK pathways.© The author(s).

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大类 | 3 区医学

小类 | 4 区肿瘤学

第一作者：

第一作者机构： [1]Department of Pharmacy, The Second Clinical Medical College of North Sichuan Medical College, Nanchong, Sichuan, China, 637003. [2]School of Pharmacy, North Sichuan Medical College, Nanchong, China, 637100.

通讯作者：

通讯机构： [1]Department of Pharmacy, The Second Clinical Medical College of North Sichuan Medical College, Nanchong, Sichuan, China, 637003. [2]School of Pharmacy, North Sichuan Medical College, Nanchong, China, 637100. [4]Nanchong Key Laboratory of Individualized Drug Therapy, Nanchong, China, 637003. [5]Department of Oncology, The Second Clinical Medical College of North Sichuan Medical College, Nanchong, China, 637003. [6]Institute of Tissue Engineering and Stem Cells, The Second Clinical Medical College of North Sichuan Medical College, Nanchong, China, 637003.

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Lasalocid inhibits melanoma by down-regulating FOXM1 through PI3K/AKT and JNK/P38 MAPK pathways

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