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Intelligent Generic High-Throughput Oscillatory Shear Technology Fabricates Programmable Microrobots for Real-Time Visual Guidance During Embolization

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机构: [1]Xiamen Univ, Ctr Mol Imaging & Translat Med, State Key Lab Mol Vaccinol & Mol Diagnost, State Key Lab Vaccines Infect Dis,Xiang Biomed Lab, Xiamen 361102, Peoples R China [2]Naval Med Univ, Naval Med Ctr PLA, Dept Gen Surg, Shanghai 200052, Peoples R China [3]North Sichuan Med Coll, Affiliated Hosp, Inst Hepatobiliary Pancreat Intestinal Dis, Dept Gen Surg, Nanchong 637000, Peoples R China [4]Xiamen Univ, Affiliated Hosp 1, Sch Med, Dept Vasc & Tumor Intervent Radiol, Xiamen 361000, Peoples R China [5]Xiamen Univ, Inst Artificial Intelligence, Xiamen 361102, Peoples R China [6]Xiamen Univ, Eye Inst, Sch Med, Fujian Prov Key Lab Ophthalmol & Visual Sci, Xiamen 361102, Peoples R China [7]Xiamen Univ, Shen Zhen Res Inst, Shenzhen 518057, Peoples R China
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关键词: endovascular embolization imaging-guided delivery machine learning microrobots real-time imaging

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Microrobots for endovascular embolization face challenges in precise delivery within dynamic blood vessels. Here, an intelligent generic high-throughput oscillatory shear technology (iGHOST) is proposed to fabricate diversely programmable, multifunctional microrobots capable of real-time visual guidance for in vivo endovascular embolization. Leveraging machine learning (ML), key synthesis parameters affecting the success and sphericity of the microrobots are identified. Therefore, the ML-optimized iGHOST enables continuous production of uniform microrobots with programmable sizes (400-1000 mu m) at an ultrahigh rate exceeding 240 mL h-1 by oscillatory segmenting fluid into droplets before ionic cross-linking, and without requiring purification. Particularly, the iGHOST-fabricated magnetically responsive lipiodol-calcium alginate (MagLiCA) microrobots are highly distinguishable under X-ray imaging, which allows for precise navigation in fluid flows of up to 4 mL min-1 and accurate embolization in liver and kidney blood vessels, thus addressing the current issues. Crucially, MagLiCA microrobots possess drug-loading capabilities, enabling simultaneous embolization and site-specific treatment. The iGHOST process is an intelligent, rapid, and green manufacturing method, which can produce size-controllable, multifunctional microrobots with the potential for precise drug delivery and treatment under real-time imaging across various medical applications.

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大类 | 2 区 材料科学
小类 | 1 区 物理:应用 2 区 化学:综合 2 区 物理化学 2 区 材料科学:综合 2 区 纳米科技 2 区 物理:凝聚态物理
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Q1 CHEMISTRY, MULTIDISCIPLINARY Q1 NANOSCIENCE & NANOTECHNOLOGY Q1 PHYSICS, APPLIED Q1 CHEMISTRY, PHYSICAL Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Q1 PHYSICS, CONDENSED MATTER

影响因子: 最新[2023版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2023版]

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第一作者机构: [1]Xiamen Univ, Ctr Mol Imaging & Translat Med, State Key Lab Mol Vaccinol & Mol Diagnost, State Key Lab Vaccines Infect Dis,Xiang Biomed Lab, Xiamen 361102, Peoples R China
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通讯机构: [1]Xiamen Univ, Ctr Mol Imaging & Translat Med, State Key Lab Mol Vaccinol & Mol Diagnost, State Key Lab Vaccines Infect Dis,Xiang Biomed Lab, Xiamen 361102, Peoples R China [7]Xiamen Univ, Shen Zhen Res Inst, Shenzhen 518057, Peoples R China
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