机构：[1]Institute of Clinical Trials, West China Hospital, Sichuan University , Chengdu, Sichuan 610041, China.四川大学华西医院[2]Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Shandong University , Jinan, Shandong 250012, China.[3]The Laboratory of Anesthesiology and Critical Care Medicine, Translational Neuroscience Center, West China Hospital, Sichuan University , Chengdu, Sichuan 610041, China.四川大学华西医院
Nitroreductase (NTR) is an endogenous reductase overexpressed in hypoxic tumors; however, its precise detection in living cells and animals remains a considerable challenge. Herein, we developed three reaction-based probes and a related bioluminescence assay for the real-time NTR detection. The high sensitivity and selectivity of probe 3, combined with its remarkable potential of bioluminescence imaging, affords a valuable approach for in vivo imaging of NTR in a tumor model mouse.
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出版当年[2016]版：
大类|1 区化学
小类|1 区分析化学
最新[2023]版：
大类|1 区化学
小类|1 区分析化学
第一作者：
第一作者机构：[1]Institute of Clinical Trials, West China Hospital, Sichuan University , Chengdu, Sichuan 610041, China.
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推荐引用方式(GB/T 7714)：
Feng Ping,Zhang Huateng,Deng Quankun,et al.Real-Time Bioluminescence Imaging of Nitroreductase in Mouse Model.[J].Analytical chemistry.2016,88(11):5610-4.doi:10.1021/acs.analchem.6b01160.
APA：
Feng Ping,Zhang Huateng,Deng Quankun,Liu Wei,Yang Linghui...&Li Minyong.(2016).Real-Time Bioluminescence Imaging of Nitroreductase in Mouse Model..Analytical chemistry,88,(11)
MLA：
Feng Ping,et al."Real-Time Bioluminescence Imaging of Nitroreductase in Mouse Model.".Analytical chemistry 88..11(2016):5610-4
化学