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Targeted delivery of organic small-molecule photothermal materials with engineered extracellular vesicles for imaging-guided tumor photothermal therapy

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收录情况： ◇ SCIE

作者：
Dong Yafang[1,2] * ; Xia Peng[2,3] * ; Xu Xiaolong[2] * ; Shen Jing[4] * ; Ding Youbin[5] ; Jiang Yuke[2] ; Wang Huifang[2] ; Xie Xin[2] ; Zhang Xiaodong[5] ; Li Weihua[6] ; Li Zhijie[2] ; Wang Jigang[1,2,7,8] ; Zhao Shan-Chao[1,9] ;
机构： [1]Department of Urology, the Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510500, P. R. China [2]Department of Nephrology, Shenzhen Key Laboratory of Kidney Diseases, Shenzhen Clinical Research Centre for Geriatrics, Shenzhen People’s Hospital, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, Guangdong 518020, P. R. China [3]Department of Hepatobiliary & Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430072, P. R. China [4]Department of Oncology, Department of Infectious Disease, Shenzhen People’s Hospital, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, Guangdong 518020, P. R. China [5]Department of Medical Imaging, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510630, P. R. China [6]Medical imaging department, Shenzhen Second People’s Hospital/the First Affiliated Hospital, Shenzhen University Health Science Center, Shenzhen, Guangdong 518035, P. R. China [7]State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, P. R. China [8]Department of Oncology, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, P. R. China [9]Department of Urology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P. R. China
出处：
DOI： 10.1186/s12951-023-02133-5
ISSN：

关键词： Imaging-guided photothermal therapy Small organic photothermal agents Croconaine dyes Extracellular vesicles Active tumor targeting

摘要：
Imaging-guided photothermal therapy (PTT) for cancers recently gathered increasing focus thanks to its precise diagnosis and potent therapeutic effectiveness. Croconaine (CR) dyes demonstrate potential in expanding utility for near infrared (NIR) dyes in bio-imaging/theranostics. However, reports on CR dyes for PTT are scarce most likely due to the short of the efficacious delivery strategies to achieve specific accumulation in diseased tissues to induce PTT. Extracellular vesicles (EVs) are multifunctional nanoparticle systems that function as safe platform for disease theragnostics, which provide potential benefits in extensive biomedical applications. Here, we developed a novel delivery system for photothermal molecules based on a CR dye that exerts photothermal activity through CDH17 nanobody-engineered EVs. The formed CR@E8-EVs showed strong NIR absorption, excellent photothermal performance, good biological compatibility and superb active tumor-targeting capability. The CR@E8-EVs can not only visualize and feature the tumors through CR intrinsic property as a photoacoustic imaging (PAI) agent, but also effectively retard the tumor growth under laser irradiation to perform PTT. It is expected that the engineered EVs will become a novel delivery vehicle of small organic photothermal agents (SOPTAs) in future clinical PTT applications.© 2023. The Author(s).

基金：
The Basic and Applied Basic Research Foundation of GuangDong Province (2021A1515012164), the International Science and Technology Cooperation for Shenzhen Technology Innovation Plan (GJHZ20200731095411034), the National Natural Science Foundation of China (No.82373775, 81972394 and 82272856), the Guangdong Basic and Applied Basic Research Foundation (No. 2020A1515010066 and 2022A1515010437), the President Foundation of The Third Affiliated Hospital of Southern Medical University (No.YM2021010), and the Shenzhen Science and Technology Innovation Commission (JCYJ20200109120205924), the Science and Technology Foundation of Shenzhen (JCYJ20210324115800001), the Science and Technology Foundation of Shenzhen (Shenzhen Clinical Medical Research Center for Geriatric Diseases), the Distinguished Expert Project of Sichuan Province Tianfu Scholar(CW202002), Shenzhen Governmental Sustainable Development Fund (KCXFZ20201221173612034); Shenzhen key Laboratory of Kidney Diseases (ZDSYS201504301616234); Shenzhen Fund for Guangdong Provincial Highlevel Clinical Key Specialties (NO.SZGSP001).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 1 区 生物学
小类 | 1 区 生物工程与应用微生物 2 区 纳米科技
最新[2023]版：
大类 | 1 区 生物学
小类 | 1 区 生物工程与应用微生物 2 区 纳米科技
JCR分区：
出版当年[2023]版：
Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q1 NANOSCIENCE & NANOTECHNOLOGY
最新[2023]版：
Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q1 NANOSCIENCE & NANOTECHNOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2022版]

第一作者：
第一作者机构： [1]Department of Urology, the Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510500, P. R. China [2]Department of Nephrology, Shenzhen Key Laboratory of Kidney Diseases, Shenzhen Clinical Research Centre for Geriatrics, Shenzhen People’s Hospital, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, Guangdong 518020, P. R. China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Urology, the Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510500, P. R. China [2]Department of Nephrology, Shenzhen Key Laboratory of Kidney Diseases, Shenzhen Clinical Research Centre for Geriatrics, Shenzhen People’s Hospital, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, Guangdong 518020, P. R. China [7]State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, P. R. China [8]Department of Oncology, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, P. R. China [9]Department of Urology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P. R. China
推荐引用方式(GB/T 7714)：
Dong Yafang,Xia Peng,Xu Xiaolong,et al.Targeted delivery of organic small-molecule photothermal materials with engineered extracellular vesicles for imaging-guided tumor photothermal therapy[J].JOURNAL OF NANOBIOTECHNOLOGY.2023,21(1):doi:10.1186/s12951-023-02133-5.
APA：
Dong Yafang,Xia Peng,Xu Xiaolong,Shen Jing,Ding Youbin...&Zhao Shan-Chao.(2023).Targeted delivery of organic small-molecule photothermal materials with engineered extracellular vesicles for imaging-guided tumor photothermal therapy.JOURNAL OF NANOBIOTECHNOLOGY,21,(1)
MLA：
Dong Yafang,et al."Targeted delivery of organic small-molecule photothermal materials with engineered extracellular vesicles for imaging-guided tumor photothermal therapy".JOURNAL OF NANOBIOTECHNOLOGY 21..1(2023)

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