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Species Diversity and Network Diversity in the Human Lung Cancer Tissue Microbiomes

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机构： [1]Computational Biology and Medical Ecology Lab, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650201, China. [2]Kunming College of Life Science, University of the Chinese Academy of Sciences, Kunming, Yunnan, 650201, China. [3]Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China. [4]Faculty of Arts and Sciences, Harvard University, Cambridge, MA 02138.

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关键词： Human lung cancer microbiome Hill numbers Shared species analysis Biodiversity on network Network link diversity Network species diversity

摘要：

This study explores the relationship between microbial diversity and disease status in human lung cancer tissue microbiomes, using a sample size of 1,212. Analysis divided the data into primary tumor (PT) and normal tissue (NT) categories. Differences in microbial diversity between PT and NT were significant in 57% of comparisons, although dataset dependence was a factor in the diversity levels. Shared species analysis (SSA) indicated no significant differences between PT and NT in over 90% of comparisons. Network diversity assessments revealed significant differences between NT and PT regarding species relative abundances and network link abundances for q=0-3. Additionally, at q=0, significant variations were found between NT and LUSC in network link probabilities, illustrating the diversity in species interactions. Our findings suggest a stable overall microbiome diversity and composition in lung cancer patients' lung tissues despite patients with diagnosed lung tumors, indicating modified microbial interactions within the tumor. These results highlight an association between altered microbiome interaction patterns and lung tumors, offering new insights into the ecological dynamics of lung cancer microbiomes.© The Author(s) 2024. Published by Oxford University Press on behalf of FEMS.

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出版当年[2025]版：

大类 | 4 区生物学

小类 | 4 区微生物学

最新[2025]版：

大类 | 4 区生物学

小类 | 4 区微生物学

第一作者：

第一作者机构： [1]Computational Biology and Medical Ecology Lab, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650201, China. [2]Kunming College of Life Science, University of the Chinese Academy of Sciences, Kunming, Yunnan, 650201, China.

通讯作者：

通讯机构： [1]Computational Biology and Medical Ecology Lab, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650201, China. [2]Kunming College of Life Science, University of the Chinese Academy of Sciences, Kunming, Yunnan, 650201, China. [4]Faculty of Arts and Sciences, Harvard University, Cambridge, MA 02138.

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Species Diversity and Network Diversity in the Human Lung Cancer Tissue Microbiomes

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