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Fine-tuning the side-chain length of iridium(III) complexes for enhanced Photophysical properties in Cancer Theranostics

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机构： [1]Huaxi MR Research Centre (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, Department of Radiology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu 610000, PR China [2]Frontiers Science Center for Flexible Electronics, Xi’an Institute of Flexible Electronics (IFE), Xi’an Institute of Biomedical Materials & Engineering, Northwestern Polytechnical University, PR China [3]School of Pharmacy, Anhui University of Traditional Chinese Medicine, Hefei 230012, PR China [4]College of Chemistry and Chemical Engineering, Anhui University, Hefei 230601, PR China [5]Department of Breast Surgery, QiLu Hospital of Shandong University, Jinan, Shandong Province 250012, China

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关键词： Theranostics Side-chain extending strategy Multi-photon absorption Cyclometalated iridium(III) complexes Intramolecular motion

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Cyclometalated iridium(III) complexes have emerged as versatile candidates for cancer theranostics, offering integrated diagnostic imaging and potent singlet oxygen (1O2) generation for photodynamic therapy (PDT). However, their application has been limited by subdued photoluminescence, primarily due to intramolecular motion-induced excited energy dissipation. In this study, we address these limitations through the design and synthesis of five novel iridium(III) complexes: IrC2, IrC4, IrC6, IrC8, and IrC12. Our approach employs meticulous side-chain extending strategy to modulate side-chain length, thereby reducing intramolecular motion and significantly enhancing both one- and three-photon emissions and 1O2 production in the aggregated state. Detailed photophysical investigations, supported by crystallographic insights, reveal that side-chain elongation substantially amplifies these properties. Among the synthesized complexes, IrC8 stands out as a superior candidate for image-guided photodynamic therapy in cellular and 3D tumor spheroid models. This investigation pioneers the simultaneous enhancement of dual-photon emissions and PDT efficacy through a novel side-chain extension strategy in iridium(III) complexes, paving the way for their translational application in clinical theranostics.Copyright © 2024 Elsevier Inc. All rights reserved.

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大类 | 2 区化学

小类 | 1 区无机化学与核化学 3 区生化与分子生物学

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第一作者机构： [1]Huaxi MR Research Centre (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, Department of Radiology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu 610000, PR China [2]Frontiers Science Center for Flexible Electronics, Xi’an Institute of Flexible Electronics (IFE), Xi’an Institute of Biomedical Materials & Engineering, Northwestern Polytechnical University, PR China

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