机构:[1]State Key Laboratory of Vaccines for Infectious Diseases & Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, China[2]State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Fujian Engineering Research Center of Molecular Theranostic Technology, School of Public Health, Xiamen University, Xiamen, 361102, China[3]Department of Interventional Radiology, The First Affiliated Hospital of Xiamen University, Xiamen, 361102, China[4]Department of General Surgery, Institute of Hepatobiliary-Pancreatic-Intestinal Diseases, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China[5]Department of Hepatobiliary and Pancreatic Surgery, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, 611731, China四川省人民医院[6]Sichuan Research Institute of Xiamen University, Chengdu, 610000, China
Cerenkov light-based excitation represents an attractive alternative to conventional external light excitation, aiming to break the penetration limitations of in vivo optical imaging and therapy. However, Cerenkov light's inherent deficiency severely restricts its potential applications in tumor theranostic. Herein, we have seamlessly integrated organometallic compounds with radio-phototheranostics for the first time, achieving significant tumor inhibition and the inaugural instance of a radionuclide(F-18)-activated NIR photosensitizer with a wavelength exceeding 800 nm through the innovative "internal-external attack" design and "two-in-one" internal energy transfer. In this study, coumarin 6 and IR775 derivatives were connected via iridium atoms to construct dual-function iridium-organometallic compounds (IR-C6Ir), combining internal and external responsive molecules for dual phototherapy and Cerenkov light red-shift fluorescence imaging. IR-C6Ir can be preferably accumulated at mitochondrial at the tumor site, inducing excellent anti-tumor effect with a 92.5 % tumor volume reduction at the lower concentration (0.65 mu M) and excitation level (800 mu Ci of F-18 and 0.5 W/cm(2) of 808 nm laser irradiation). In addition, IR-C6Ir-mediated internal and external phototherapy exhibited the synergistic enhancement effect of "1 + 1>2" and achieved tumor multiplex visualization. The combination of internal phototherapy and external phototherapy motifs in one molecule, provides IR-C6Ir with a novel strategy for high-efficiency and low-toxicity phototherapy.
基金:
National Key Research and Development Program of China [2023YFB3810000, 2023YFC241570]; National Natural Science Foundation of China (NSFC) [32101113, 82302403, 82402426, 81925019, U22A20333, U24A20525]; Xiamen Medical Research Fund [2022J011385, K2023-02, K2023-31, 2024Y9716, 2025XAKJ0201002]; Shenzhen Medical Research Fund [B2302014]; Natural Science Foundation of Sichuan Province [2024ZX02, 2024NSFSC1741, 2024YBUYXJJ051]; Fundamental Research Funds for the Central Universities [20720240051]; Postdoctoral Fellowship Program of CPSF [GZC20231400]
第一作者机构:[1]State Key Laboratory of Vaccines for Infectious Diseases & Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, China[6]Sichuan Research Institute of Xiamen University, Chengdu, 610000, China
共同第一作者:
通讯作者:
通讯机构:[1]State Key Laboratory of Vaccines for Infectious Diseases & Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, China[6]Sichuan Research Institute of Xiamen University, Chengdu, 610000, China
推荐引用方式(GB/T 7714):
An Yibo,Li Man,He Pan,et al.Ir-organometallic compounds-mediated internal and external dual-phototheranostics for collaborative antitumor therapy[J].BIOMATERIALS.2025,322:doi:10.1016/j.biomaterials.2025.123400.
APA:
An, Yibo,Li, Man,He, Pan,Tan, Yubo,Liu, Renyuan...&Lu, Zhixiang.(2025).Ir-organometallic compounds-mediated internal and external dual-phototheranostics for collaborative antitumor therapy.BIOMATERIALS,322,
MLA:
An, Yibo,et al."Ir-organometallic compounds-mediated internal and external dual-phototheranostics for collaborative antitumor therapy".BIOMATERIALS 322.(2025)