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Ir-organometallic compounds-mediated internal and external dual-phototheranostics for collaborative antitumor therapy

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机构: [1]State Key Laboratory of Vaccines for Infectious Diseases & Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, China [2]State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, Fujian Engineering Research Center of Molecular Theranostic Technology, School of Public Health, Xiamen University, Xiamen, 361102, China [3]Department of Interventional Radiology, The First Affiliated Hospital of Xiamen University, Xiamen, 361102, China [4]Department of General Surgery, Institute of Hepatobiliary-Pancreatic-Intestinal Diseases, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China [5]Department of Hepatobiliary and Pancreatic Surgery, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, 611731, China [6]Sichuan Research Institute of Xiamen University, Chengdu, 610000, China
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关键词: Cerenkov light Photodynamic therapy Theranostics

摘要:
Cerenkov light-based excitation represents an attractive alternative to conventional external light excitation, aiming to break the penetration limitations of in vivo optical imaging and therapy. However, Cerenkov light's inherent deficiency severely restricts its potential applications in tumor theranostic. Herein, we have seamlessly integrated organometallic compounds with radio-phototheranostics for the first time, achieving significant tumor inhibition and the inaugural instance of a radionuclide(F-18)-activated NIR photosensitizer with a wavelength exceeding 800 nm through the innovative "internal-external attack" design and "two-in-one" internal energy transfer. In this study, coumarin 6 and IR775 derivatives were connected via iridium atoms to construct dual-function iridium-organometallic compounds (IR-C6Ir), combining internal and external responsive molecules for dual phototherapy and Cerenkov light red-shift fluorescence imaging. IR-C6Ir can be preferably accumulated at mitochondrial at the tumor site, inducing excellent anti-tumor effect with a 92.5 % tumor volume reduction at the lower concentration (0.65 mu M) and excitation level (800 mu Ci of F-18 and 0.5 W/cm(2) of 808 nm laser irradiation). In addition, IR-C6Ir-mediated internal and external phototherapy exhibited the synergistic enhancement effect of "1 + 1>2" and achieved tumor multiplex visualization. The combination of internal phototherapy and external phototherapy motifs in one molecule, provides IR-C6Ir with a novel strategy for high-efficiency and low-toxicity phototherapy.

基金:

基金编号: 2023YFB3810000 2023YFC241570 32101113 82302403 82402426 81925019 U22A20333 U24A20525 2022J011385 K2023-02 K2023-31 2024Y9716 2025XAKJ0201002 B2302014 2024ZX02 2024NSFSC1741 2024YBUYXJJ051 20720240051 GZC20231400

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出版当年[2025]版:
大类 | 1 区 医学
小类 | 1 区 工程:生物医学 1 区 材料科学:生物材料
最新[2025]版:
大类 | 1 区 医学
小类 | 1 区 工程:生物医学 1 区 材料科学:生物材料
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出版当年[2024]版:
Q1 ENGINEERING, BIOMEDICAL Q1 MATERIALS SCIENCE, BIOMATERIALS
最新[2024]版:
Q1 ENGINEERING, BIOMEDICAL Q1 MATERIALS SCIENCE, BIOMATERIALS

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第一作者机构: [1]State Key Laboratory of Vaccines for Infectious Diseases & Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, China [6]Sichuan Research Institute of Xiamen University, Chengdu, 610000, China
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通讯机构: [1]State Key Laboratory of Vaccines for Infectious Diseases & Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, China [6]Sichuan Research Institute of Xiamen University, Chengdu, 610000, China
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