资源类型：
期刊
Pubmed体系：
Journal Article
文章类型：
论著
作者：
Bauer Tobias[1,2]
;
von Wrede Randi D[2]
;
Pujar Suresh[3]
;
Rácz Attila[2]
;
Hoppe Christian[2]
;
Baumgartner Tobias[2]
;
Varadkar Sophia[3,4]
;
Held Nina R[1,2]
;
Reiter Johannes T[1,2]
;
Enders Selma[2]
;
David Bastian[2]
;
Prillwitz Conrad C[2]
;
Brugues Mar[5]
;
Keil Vera C W[2,6,7,8]
;
Jeub Monika[2]
;
Borger Valeri[9]
;
Sander Josemir W[10,11,12]
;
Kunz Wolfram S[2,13]
;
Radbruch Alexander[1]
;
Weber Bernd[13]
;
Helmstaedter Christoph[2]
;
Vatter Hartmut[9]
;
Baldeweg Torsten[4]
;
Becker Albert J[5]
;
Cross J Helen[3,4,14]
;
Surges Rainer[2]
;
Rüber Theodor[1,2]
;
机构：
[1]Department of Neuroradiology, University Hospital Bonn, Bonn, Germany
[2]Department of Epileptology, University Hospital Bonn, Bonn, Germany
[3]Department of Neurology, Great Ormond Street Hospital for Children, London, UK
[4]Developmental Neurosciences Research and Teaching Department, UCL NIHR BRC Great Ormond Street Institute of Child Health, London, UK
[5]Section for Translational Epilepsy Research, Department of Neuropathology, University Hospital Bonn, Bonn, Germany
[6]Department of Radiology and Nuclear Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands
[7]Amsterdam Neuroscience, Brain Imaging Amsterdam, Amsterdam, The Netherlands
[8]Cancer Center Amsterdam, Imaging and Biomarkers, Amsterdam, The Netherlands
[9]Department of Neurosurgery, University Hospital Bonn, Bonn, Germany
[10]Department of Clinical & Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK
[11]Chalfont Centre for Epilepsy, Chalfont St Peter, UK
[12]Department of Neurology, West China Hospital, Sichuan University, Chengdu, China
四川大学华西医院
[13]Institute of Experimental Epileptology and Cognition Research, University Hospital Bonn, Bonn, Germany
[14]Young Epilepsy Lingfeld, Lingfeld, UK
ISSN：
0340-5354
关键词：
Epilepsy
EEG
Neuroimmunology
Neuropsychology
MRI
摘要：
Progressive inflammation of one hemisphere characterises Rasmussen's encephalitis (RE), but contralesional epileptiform activity has been repeatedly reported. We aimed to quantify contralesional epileptiform activity in RE and uncover its functional and structural underpinnings. We retrospectively ascertained people with RE treated between 2000 and 2018 at a tertiary centre (Centre 1) and reviewed all available EEG datasets. The temporal occurrence of preoperative contralesional epileptiform activity (interictal/ictal) was evaluated using mixed-effects logistic regression. Cases with/without contralesional epileptiform activity were compared for cognition, inflammation (ipsilesional brain biopsies), and MRI (cortical and fixel-based morphometry). EEG findings were validated in a second cohort treated at another tertiary centre (Centre 2) between 1995 and 2020. We included 127 people with RE and 687 EEG samples. Preoperatively, contralesional epileptiform activity was seen in 30/68 (44%, Centre 1) and 8/59 (14%, Centre 2). In both cohorts, this activity was associated with younger onset age (OR = 0.9; 95% CI 0.83-0.97; P = 0.006). At centre 1, contralesional epileptiform activity was associated with contralesional MRI alterations, lower intelligence (OR = 5.19; 95% CI 1.28-21.08; P = 0.021), and impaired verbal memory (OR = 10.29; 95% CI 1.97-53.85; P = 0.006). After hemispherotomy, 11/17 (65%, Centre 1) and 28/37 (76%, Centre 2) were seizure-free. Contralesional epileptiform activity was persistent postoperatively in 6/12 (50%, Centre 1) and 2/34 (6%, Centre 2). Preoperative contralesional epileptiform activity reduced the chance of postoperative seizure freedom in both cohorts (OR = 0.69; 95% CI 0.50-0.95; P = 0.029). Our findings question the concept of strict unilaterality of RE and provide the evidence of contralesional epileptiform activity as a possible EEG predictor for persisting postoperative seizures.© 2024. The Author(s).
基金：
Projekt
DEAL. T. Bauer received funding from the BONFOR research commission of the Medical Faculty of the University of Bonn (Grant 2022-1A-21).
PubmedID：
39138652
中科院(CAS)分区：
出版当年[2023]版：
大类
|
2 区
医学
小类
|
2 区
临床神经病学
最新[2023]版：
大类
|
2 区
医学
小类
|
2 区
临床神经病学
第一作者：
Bauer Tobias
第一作者机构：
[1]Department of Neuroradiology, University Hospital Bonn, Bonn, Germany
[2]Department of Epileptology, University Hospital Bonn, Bonn, Germany
共同第一作者：
von Wrede Randi D
通讯作者：
Rüber Theodor
通讯机构：
[1]Department of Neuroradiology, University Hospital Bonn, Bonn, Germany
[2]Department of Epileptology, University Hospital Bonn, Bonn, Germany
推荐引用方式(GB/T 7714)：
Bauer Tobias,von Wrede Randi D,Pujar Suresh,et al.Rasmussen's encephalitis: structural, functional, and clinical correlates of contralesional epileptiform activity[J].Journal Of Neurology.2024,doi:10.1007/s00415-024-12607-7.
APA：
Bauer Tobias,von Wrede Randi D,Pujar Suresh,Rácz Attila,Hoppe Christian...&Rüber Theodor.(2024).Rasmussen's encephalitis: structural, functional, and clinical correlates of contralesional epileptiform activity.Journal Of Neurology,,
MLA：
Bauer Tobias,et al."Rasmussen's encephalitis: structural, functional, and clinical correlates of contralesional epileptiform activity".Journal Of Neurology .(2024)
医学