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Current understanding of functional peptides encoded by lncRNA in cancer

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机构： [1]Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou 646000, China [2]Cell Therapy and Cell Drugs of Luzhou Key Laboratory, Luzhou 646000, China [3]South Sichuan Institute of Translational Medicine, Luzhou 646000, China [4]School of Nursing, Chongqing College of Humanities, Science & Technology, Chongqing, China [5]Department of Pathology, The Afliated Hospital of Southwest Medical University, Luzhou, China 646000 [6]Gulin Traditional Chinese Medicine Hospital, Luzhou, China [7]Department of Pharmacology, School of Pharmacy, Sichuan College of Traditional Chinese Medicine, Mianyang, China

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关键词： Cancer Coding potential Functional peptides lncRNA Small ORF

摘要：

Dysregulated gene expression and imbalance of transcriptional regulation are typical features of cancer. RNA always plays a key role in these processes. Human transcripts contain many RNAs without long open reading frames (ORF, > 100 aa) and that are more than 200 bp in length. They are usually regarded as long non-coding RNA (lncRNA) which play an important role in cancer regulation, including chromatin remodeling, transcriptional regulation, translational regulation and as miRNA sponges. With the advancement of ribosome profiling and sequencing technologies, increasing research evidence revealed that some ORFs in lncRNA can also encode peptides and participate in the regulation of multiple organ tumors, which undoubtedly opens a new chapter in the field of lncRNA and oncology research. In this review, we discuss the biological function of lncRNA in tumors, the current methods to evaluate their coding potential and the role of functional small peptides encoded by lncRNA in cancers. Investigating the small peptides encoded by lncRNA and understanding the regulatory mechanisms of these functional peptides may contribute to a deeper understanding of cancer and the development of new targeted anticancer therapies.© 2024. The Author(s).

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大类 | 2 区医学

小类 | 3 区肿瘤学

第一作者：

第一作者机构： [1]Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou 646000, China [2]Cell Therapy and Cell Drugs of Luzhou Key Laboratory, Luzhou 646000, China [3]South Sichuan Institute of Translational Medicine, Luzhou 646000, China [4]School of Nursing, Chongqing College of Humanities, Science & Technology, Chongqing, China

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通讯机构： [1]Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou 646000, China [2]Cell Therapy and Cell Drugs of Luzhou Key Laboratory, Luzhou 646000, China [3]South Sichuan Institute of Translational Medicine, Luzhou 646000, China [6]Gulin Traditional Chinese Medicine Hospital, Luzhou, China [7]Department of Pharmacology, School of Pharmacy, Sichuan College of Traditional Chinese Medicine, Mianyang, China

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