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Functional Peptides Encoded by Long Non-Coding RNAs in Gastrointestinal Cancer.

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机构： [1]Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, China [2]South Sichuan Institute of Translational Medicine, Luzhou, China [3]Laboratory of Personalised Cell Therapy & Cell Medicines, School of Pharmacy, Southwest Medical University, Luzhou, China [4]School of Basic Medicine, Southwest Medical University, Luzhou, China [5]Department of Pathology, The Affiliated Hospital of Southwest Medical University, Luzhou, China [6]Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, China [7]School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, Hong Kong SAR, China

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关键词： long non-coding RNA (lncRNA) ORF small peptide gastrointestinal cancer function

摘要：

Gastrointestinal cancer is by far the most common malignancy and the most common cause of cancer-related deaths worldwide. Recent studies have shown that long non-coding RNAs (lncRNAs) play an important role in the epigenetic regulation of cancer cells and regulate tumor progression by affecting chromatin modifications, gene transcription, translation, and sponge to miRNAs. In particular, lncRNA has recently been found to possess open reading frame (ORF), which can encode functional small peptides or proteins. These peptides interact with its targets to regulate transcription or the signal axis, thus promoting or inhibiting the occurrence and development of tumors. In this review, we summarize the involvement of lncRNAs and the function of lncRNAs encoded small peptides in gastrointestinal cancer.Copyright © 2021 Chen, Long, Yang, Zhao, Wu, Li, Du, Chen, Yang, Wen, Yi, Xiao and Shen.

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出版当年[2021]版：

大类 | 3 区医学

小类 | 3 区肿瘤学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区肿瘤学

第一作者：

第一作者机构： [1]Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, China [2]South Sichuan Institute of Translational Medicine, Luzhou, China [3]Laboratory of Personalised Cell Therapy & Cell Medicines, School of Pharmacy, Southwest Medical University, Luzhou, China

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通讯作者：

通讯机构： [1]Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, China [2]South Sichuan Institute of Translational Medicine, Luzhou, China [3]Laboratory of Personalised Cell Therapy & Cell Medicines, School of Pharmacy, Southwest Medical University, Luzhou, China

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