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Consensus statement on extracellular vesicles in liquid biopsy for advancing laboratory medicine

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机构: [1]558113 Central Laboratory, Department of Hematology and Oncology, Shenzhen Key Laboratory of Precision Medicine for Hematological Malignancies, Shenzhen Clinical Research Center for hematologic disease, Shenzhen University General Hospital , Shenzhen, Guangdong, 518000, China. [2]Department of Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. [3]Department of Thoracic Surgery, 47885 The First Affiliated Hospital of Jinan University , Guangzhou 510632, China. [4]Institute of Precision Cancer Medicine and Pathology, School of Medicine, Guangzhou, China. [5]State Key Laboratory of Bioactive Molecules and Druggability Assessment, and MOE Key Laboratory of Tumor Molecular Biology, Jinan University, Guangzhou 510632, China. [6]74623 School of Basic Medicine and Forensic Medicine, Henan University of Science & Technology , Luoyang 471023, China. [7]Biotherapy Center, Harbin Medical University Cancer Hospital, Heilongjiang Province, Harbin 150081, China. [8]NHC Key Laboratory of Cell Transplantation, Harbin Medical University, Heilongjiang Province, Harbin 150081, China. [9]State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. [10]Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, and College of Pharmacy, State Key Laboratory of Bioactive Molecules and Druggability Assessment, and MOE Key Laboratory of Tumor Molecular Biology, Jinan University, Guangzhou 510632, China. [11]Department of Oral Pathology, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, China. [12]Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University, Shanghai, China. [13]47885 MOE Key Laboratory of Tumor Molecular Biology, College of Life Science and Technology, Jinan University , Guangzhou 510632, China. [14]Department of Chemical Biology, 534787 MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Key Laboratory for Chemical Biology of Fujian Province, Collaborative Innovation Center of Chemistry for Energy Materials, College of Chemistry and Chemical Engineering, Xiamen University , Xiamen, China. [15]12377 MOE Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University , Hangzhou, China. [16]Department of Hepatobiliary Surgery, 558113 Shenzhen Key Laboratory, Shenzhen University General Hospital , Shenzhen, Guangdong, China. [17]Department of Medical Oncology, 159407 The First Hospital of China Medical University , Shenyang, China. [18]Key Laboratory of Birth Defects and Related Diseases of Women and Children, Department of Paediatrics, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, China. [19]Cancer Care Centre, St George Hospital, Kogarah, NSW 2217, Australia. [20]St George and Sutherland Clinical Campuses, School of Clinical Medicine, UNSW Sydney, Kensington, NSW, Australia. [21]Institute of Precision Cancer Medicine and Pathology, and Department of Pathology, School of Medicine, Jinan University, Guangzhou, P.R. China.
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关键词: extracellular vesicles cancer biology clinical oncology liquid biopsy diagnostics therapeutics

摘要:
Extracellular vesicles (EVs) represent a diverse class of nanoscale membrane vesicles actively released by cells. These EVs can be further subdivided into categories like exosomes and microvesicles, based on their origins, sizes, and physical attributes. Significantly, disease-derived EVs have been detected in virtually all types of body fluids, providing a comprehensive molecular profile of their cellular origins. As a result, EVs are emerging as a valuable addition to liquid biopsy techniques. In this collective statement, the authors share their current perspectives on EV-related research and product development, with a shared commitment to translating this newfound knowledge into clinical applications for cancer and other diseases, particularly as disease biomarkers. The consensus within this document revolves around the overarching recognition of the merits, unresolved questions, and existing challenges surrounding EVs. This consensus manuscript is a collaborative effort led by the Committee of Exosomes, Society of Tumor Markers, Chinese anti-Cancer Association, aimed at expediting the cultivation of robust scientific and clinically applicable breakthroughs and propelling the field forward with greater swiftness and efficacy.© 2024 Walter de Gruyter GmbH, Berlin/Boston.

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大类 | 2 区 医学
小类 | 2 区 医学实验技术
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大类 | 2 区 医学
小类 | 2 区 医学实验技术
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Q1 MEDICAL LABORATORY TECHNOLOGY
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Q1 MEDICAL LABORATORY TECHNOLOGY

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第一作者机构: [1]558113 Central Laboratory, Department of Hematology and Oncology, Shenzhen Key Laboratory of Precision Medicine for Hematological Malignancies, Shenzhen Clinical Research Center for hematologic disease, Shenzhen University General Hospital , Shenzhen, Guangdong, 518000, China.
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通讯机构: [5]State Key Laboratory of Bioactive Molecules and Druggability Assessment, and MOE Key Laboratory of Tumor Molecular Biology, Jinan University, Guangzhou 510632, China. [19]Cancer Care Centre, St George Hospital, Kogarah, NSW 2217, Australia. [20]St George and Sutherland Clinical Campuses, School of Clinical Medicine, UNSW Sydney, Kensington, NSW, Australia. [21]Institute of Precision Cancer Medicine and Pathology, and Department of Pathology, School of Medicine, Jinan University, Guangzhou, P.R. China.
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