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Application of bacterial extracellular vesicles in gastrointestinal diseases

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机构： [1]Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China , Menghang Zu1 , Baoyi Li1 , Rui L. Reis2 [2]3Bs Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables, and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Barco, Guimarães, 4805-694, Portugal ,3 [3]ICVS/3B’s-PT Government Associate Laboratory, Braga, Guimarães 4800-058, Portugal

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Bacterial extracellular vesicles (BEVs) are nanoscale spherical particles with lipid bilayer membranes containing diverse functional components from their parent bacteria. They exert pivotal effects on bacteria-bacteria and host-bacteria communication. Analyzing the dynamic changes in the production and composition of BEVs provides insights into the relationship between gut microbiota and host health, offering valuable perspectives for diagnosing various gastrointestinal diseases. Furthermore, BEVs can be employed as natural medications and drug delivery vehicles for inflammation management, cancer treatment, and vaccine development. This review summarizes the structural composition, generation mechanism, and biomedical applications of BEVs, emphasizing recent advances in immune regulation, gut microbiota modulation, and the clinical translation challenges associated with gastrointestinal diseases.Copyright © 2025 Elsevier Ltd. All rights reserved.

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出版当年[2025]版中科院分区表Review为是的期刊

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大类 | 1 区

生物学

小类 | 1 区生物工程与应用微生物

最新[2025]版

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大类 | 1 区

生物学

小类 | 1 区生物工程与应用微生物

第一作者：

第一作者机构： [1]Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China , Menghang Zu1 , Baoyi Li1 , Rui L. Reis2

通讯作者：

通讯机构： [2]3Bs Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables, and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Barco, Guimarães, 4805-694, Portugal ,3 [3]ICVS/3B’s-PT Government Associate Laboratory, Braga, Guimarães 4800-058, Portugal

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