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Pan-cancer single-cell landscape of drug-metabolizing enzyme genes

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资源类型：
Pubmed体系：
作者：
Mao Wei[1] ; Zhou Tao[1] ; Zhang Feng[2] ; Qian Maoxiang[3] ; Xie Jianqiang[4] ; Li Zhengyan[5] ; Shu Yang[6] ; Li Yuan[7] ; Xu Heng[1,*1] ;
机构： [1]Department of Laboratory Medicine/Research Centre of Clinical Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan. [2]Center for Precision Medicine, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, Zhejiang. [3]Institute of Pediatrics and Department of Hematology and Oncology, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai. [4]Department of Medicine and Surgery, Sichan Second Veterans Hospital. [5]Department of Radiology, West China Hospital, Sichuan University. [6]Gastric Cancer Center, West China Hospital, Sichuan University. [7]Institute of Digestive Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
出处：
DOI： 10.1097/FPC.0000000000000538
ISSN：

关键词： antitumor therapy cellular heterogeneity drug metabolism drug-metabolizing enzymes personalized medicine single-cell RNA sequencing

摘要：
Varied expression of drug-metabolizing enzymes (DME) genes dictates the intensity and duration of drug response in cancer treatment. This study aimed to investigate the transcriptional profile of DMEs in tumor microenvironment (TME) at single-cell level and their impact on individual responses to anticancer therapy.Over 1.3 million cells from 481 normal/tumor samples across 9 solid cancer types were integrated to profile changes in the expression of DME genes. A ridge regression model based on the PRISM database was constructed to predict the influence of DME gene expression on drug sensitivity.Distinct expression patterns of DME genes were revealed at single-cell resolution across different cancer types. Several DME genes were highly enriched in epithelial cells (e.g. GPX2, TST and CYP3A5) or different TME components (e.g. CYP4F3 in monocytes). Particularly, GPX2 and TST were differentially expressed in epithelial cells from tumor samples compared to those from normal samples. Utilizing the PRISM database, we found that elevated expression of GPX2, CYP3A5 and reduced expression of TST was linked to enhanced sensitivity of particular chemo-drugs (e.g. gemcitabine, daunorubicin, dasatinib, vincristine, paclitaxel and oxaliplatin).Our findings underscore the varied expression pattern of DME genes in cancer cells and TME components, highlighting their potential as biomarkers for selecting appropriate chemotherapy agents.Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.

基金：
National Key R&D Program of China (No. 2023YFC3405200), the Sichuan Science & Technology Program (2022NSFSC0840), 1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University (No. ZYYC23025 and No. ZYYC23013).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 3 区 医学
小类 | 3 区 生物工程与应用微生物 3 区 遗传学 3 区 药学
最新[2023]版：
大类 | 3 区 医学
小类 | 3 区 生物工程与应用微生物 3 区 遗传学 3 区 药学
第一作者：
第一作者机构： [1]Department of Laboratory Medicine/Research Centre of Clinical Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan.
共同第一作者：
通讯作者：
通讯机构： [1]Department of Laboratory Medicine/Research Centre of Clinical Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan. [*1]Department of Laboratory Medicine/ Research Centre of Clinical Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, No. 17, Section 3, South Renmin Road, Chengdu, Sichuan, China
推荐引用方式(GB/T 7714)：
Mao Wei,Zhou Tao,Zhang Feng,et al.Pan-cancer single-cell landscape of drug-metabolizing enzyme genes[J].Pharmacogenetics And Genomics.2024,doi:10.1097/FPC.0000000000000538.
APA：
Mao Wei,Zhou Tao,Zhang Feng,Qian Maoxiang,Xie Jianqiang...&Xu Heng.(2024).Pan-cancer single-cell landscape of drug-metabolizing enzyme genes.Pharmacogenetics And Genomics,,
MLA：
Mao Wei,et al."Pan-cancer single-cell landscape of drug-metabolizing enzyme genes".Pharmacogenetics And Genomics .(2024)

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