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Biological clock regulation by the PER gene family: a new perspective on tumor development

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机构： [1]Department of Urology, The First Hospital of Jiaxing, The Affiliated Hospital of Jiaxing University, Jia Xing, China. [2]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China. [3]Department of Urology, The Third Medical Center of PLA General Hospital, Beijing, China. [4]Division of Surgery and Interventional Science, University College London, London, United Kingdom.

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关键词： period gene circadian rhythm carcinogenic effect biological behavior cancer therapy

摘要：

The Period (PER) gene family is one of the core components of the circadian clock, with substantial correlations between the PER genes and cancers identified in extensive researches. Abnormal mutations in PER genes can influence cell function, metabolic activity, immunity, and therapy responses, thereby promoting the initiation and development of cancers. This ultimately results in unequal cancers progression and prognosis in patients. This leads to variable cancer progression and prognosis among patients. In-depth studies on the interactions between the PER genes and cancers can reveal novel strategies for cancer detection and treatment. In this review, we aim to provide a comprehensive overview of the latest research on the role of the PER gene family in cancer.Copyright © 2024 Chen, Wang, Li, Wu, Wang, Wei, Zhu, Xie, Feng and He.

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大类 | 2 区生物学

小类 | 2 区发育生物学 3 区细胞生物学

第一作者：

第一作者机构： [1]Department of Urology, The First Hospital of Jiaxing, The Affiliated Hospital of Jiaxing University, Jia Xing, China. [2]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.

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通讯机构： [2]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China. [4]Division of Surgery and Interventional Science, University College London, London, United Kingdom.

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Biological clock regulation by the PER gene family: a new perspective on tumor development

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