The circadian clock is an evolutionary molecular product that is associated with better adaptation to changes in the external environment. Disruption of the circadian rhythm plays a critical role in tumorigenesis of many kinds of cancers, including prostate cancer (PCa). Integrating circadian rhythm into PCa research not only brings a closer understanding of the mechanisms of PCa but also provides new and effective options for the precise treatment of patients with PCa. This review begins with patterns of the circadian clock, highlights the role of the disruption of circadian rhythms in PCa at the epidemiological and molecular levels, and discusses possible new approaches to PCa therapy that target the circadian clock.
基金：
National Natural Science Foundation of
China (grant No. 81974099, 82170785, 81974098, and 82170784), a program
from Science and Technology Department of Sichuan Province (grant No.
21GJHZ0246), Young Investigator Award of Sichuan University 2017 (grant
No. 2017SCU04A17), Technology Innovation Research and Development
Project of Chengdu Science and Technology Bureau (2019-YF05-00296-SN),
and Sichuan University-Panzhihua Science and Technology Cooperation Special
fund (2020CDPZH-4).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类|2 区医学
小类|2 区男科学2 区泌尿学与肾脏学
最新[2023]版：
大类|2 区医学
小类|3 区男科学3 区泌尿学与肾脏学
第一作者：
第一作者机构：[1]Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Zhu Wei-Zhen,He Qi-Ying,Feng De-Chao,et al.Circadian rhythm in prostate cancer: time to take notice of the clock[J].Asian Journal of Andrology.2022,doi:10.4103/aja202255.
APA：
Zhu Wei-Zhen,He Qi-Ying,Feng De-Chao,Wei Qiang&Yang Lu.(2022).Circadian rhythm in prostate cancer: time to take notice of the clock.Asian Journal of Andrology,,
MLA：
Zhu Wei-Zhen,et al."Circadian rhythm in prostate cancer: time to take notice of the clock".Asian Journal of Andrology .(2022)
